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?? ??:: 1017241-36-9

???:: ???????????

???(??):: ???????????

???:: Olanzapine ThiolactaM IMpurity

???(??):: Olanzapine ThiolactaM;Olanzapine ThiolactuM;Olanzapine Impurity 11;Olanzapine EP Impurity E;Olanzapine Ketothiolactam;lanzapine ThiolactaM IMpurity;Olanzapine Thiolactum Impurity;Olanzapine Thiolactam Impurity;Olanzapine Impurity 5(Olanzapine EP Impurity E);Olanzapine impurity 3（Olanzapine EP Impurity E）

CBNumber:: CB92545515

???:: C17H20N4OS

??? ??:: 328.43

MOL ??:: 1017241-36-9.mol

??

??

??

?? ?? 84

??????????? ??

???: 167-168°C (dec.)

?? ?: 476.9±55.0 °C(Predicted)

??: 1.28±0.1 g/cm3(Predicted)

?? ??: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

???: DMSO (Slightly, Heated), Methanol (Slightly, Heated)

??? ??: ??

??? ??: ??? ??

?? ?? (pKa): 9.49±0.40(Predicted)

??: ?? ????? ?? ?????

???: ???

??

?? ? ?? ??
?? ? ???? ?? (GHS)

HS ??	29339900

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??		P264, P270, P301+P312, P330, P501
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??		P264, P280, P305+P351+P338,P337+P313P

??????:

P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P330	?? ?????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.
P501	...? ??? / ??? ?? ???.

NFPA 704

	0
2		0

??????????? C??? ??, ??, ??

??? ??

Brownish Yellow Solid

??

A degradation product of Olanzapine (LY170053) (O253750) in solid oral formulations.

??????????? ?? ?? ? ???

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???( 84)?? ??

???	??	???	??	?? ?	??
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??????????? ?? ??:

1-????-2-?????? Thiopropionamide Thioacetamide Olanzapine LactaM IMpurity 5-Methyl-2-[(2-nitrophenyl)amino]thiophene-3-carbonitrile OLANZAPINE N-OXIDE HydroxyMethylidene thione 2-(1,2-PhenylenediaMino)-5-Methylthiphene-3-carbonitrile (E)-1-(4-(2-Methyl-10H-benzo[b]thieno[2,3-e][1,4]diazepin-4-yl)piperazin-1-yl)ethanone 1-(ChloroMethyl)-1-Methyl-4-(2-Methyl-10H-thieno[2,3-b][1,5]benzodiazepin-4-yl)-piperaziniuM Chloride Olanzapine ThioacetoxyMethylidene IMpurity Discontinued 2-Amino-5-methyl-3-thiophenecarbonitrile 2-Methyl-4-(1-piperazinyl)-10H-thienol[2,3-b][1,5]benzodiazepine 1-Methylpiperazine 4-Amino-2-methyl-10H-thiene[2,3-b][1,5]benzodiazepine hydrochloride Olanzapine 2-Propylidenepropanedinitrile 5,10-Dihydro-2-methyl-4H-thieno[2,3-β][1,5]benzodiazepin-4-one (Olanzapine Impurity)

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