ChemicalBook >?? ???? >??? ??>???>?? ?? ??>???? ???>3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone ??
- ???
- 289 °C
- ?? ?
- 522.5±60.0 °C(Predicted)
- ??
- 1.57±0.1 g/cm3(Predicted)
- ?? ??
- -20°C
- ???
- DMSO: >20mg/mL
- ??? ??
- ?? ??
- ?? ?? (pKa)
- 9.91±0.20(Predicted)
- ??
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- ??? ?? ?????? 2? ?? ??????. DMSO ??? -20°C?? ?? 3?? ?? ??? ? ????.
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- ?? ? ???? ?? (GHS)
| WGK ?? | 3 | ||
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| HS ?? | 2933.59.8000 |
| ????(GHS): |
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone C??? ??, ??, ??
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Mdivi 1 is a mitochondrial division inhibitor. It inhibits the GTPase activity of yeast, but not human, dynamin-1 (Dnm1; IC50 = ~1-10 μM for the recombinant yeast enzyme) and human dynamin-related protein 1 (DRP1) in A549 lung cancer cells when used at a concentration of 50 μM. Mdivi 1 (50 μM) inhibits mitochondrial fragmentation and DRP1 self-assembly induced by staurosporine in COS cells overexpressing DRP1. It induces apoptosis in, and inhibits colony formation of, A549 cells when used at concentrations of 25 and 50 μM, respectively. Mdivi 1 (1 μM) decreases doxorubicin-induced increases in infarct-to-risk ratios in a Langendorff isolated perfused rat heart model of ischemia-reperfusion injury. It reduces the severity of lung injury in a mouse model of LPS-induced acute lung injury when administered at a dose of 20 mg/kg.??
Mdivi-1 is an inhibitor of mitochondrial division DRP1 and Dynamin I.?? ??
Mitochondrial Division Inhibitor 1 (Mdivi-1) is a quinazolinone derivative and is cell permeable. It traverses blood-brain barrier and elicits protective functionality in heart and brain ischemia-reperfusion injury.3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone ?? ?? ? ???
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone ?? ??
???( 140)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
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3-(2,4-Dichloro-5-methoxyphenyl)-2,3-dihydro-2-thioxo-4(1H)-quinazolinone ?? ??:
p-Anisidine
CHLOROPHENYLSILANE 97
Phenylsilane
Phenyltrichlorosilane
COENZYME Q2
7-CHLORO-5-(2-CHLOROPHENYL)-1,5-DIHYDRO-4,1-BENZOTHIAZEPIN-2(3H)-ONE
Melatonine
BONGKREKIC ACID
BA, 3NH4
CARBONYL CYANIDE 3-CHLOROPHENYLHYDRAZONE
DECYLUBIQUINONE
FCCP
N4-(9-Ethyl-9H-carbazol-3-yl)-N2-(3-Morpholin-4-yl-propyl)-pyriMidine-2,4-diaMine
Y27632 (hydrochloride)
SB 431542
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SB 203580
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