ChemicalBook >?? ???? >????B
????B
|
|
????B ??
- ???
- 200~203℃
- ?? ?
- 693.0±55.0 °C(Predicted)
- ??
- 1.35±0.1 g/cm3(Predicted)
- ?? ??
- Store at -20°C
- ???
- DMSO: ??? ? ??
- ??? ??
- ??
- ?? ?? (pKa)
- 12.11±0.70(Predicted)
- ??
- White to off-white
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
????B C??? ??, ??, ??
??
Territrem B (TRB) is a fungal metabolite isolated from Aspergillus terreus shown previously to be a potent and irreversible inhibitor of acetylcholinesterase (AChE).??
Territrem B is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem B is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.???? ??
Territrem B is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 19 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.21 mg/kg, and has an LD50 value of 9.06 mg/kg.?? ??
Territrems, tremorgenic mycotoxins of Aspergillus terreus. Ling K.L. et al., Appl. Env. Microbiol. 1979, 37, 355.Toxicity and anticholinesterase activity of the fungal metabolites territrems to the corn earworm, Helicoverpa zea. Dowd P.F. et al., Entomol. Exp. Appl. 1992, 65, 57.
Territrem B, a tremorgenic mycotoxin that inhibits acetylcholinesterase with a noncovalent yet irreversible binding mechanism. Jen-Wei Chen J-W. et al., J. Biol. Chem. 1999, 274, 34916.
????B ?? ?? ? ???
???
?? ??
????B ?? ??
???( 39)?? ??
??? | ?? | ??? | ?? | ?? ? | ?? |
---|---|---|---|---|---|
Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30239 | 58 |
BOC Sciences | 16314854226; +16314854226 |
inquiry@bocsci.com | United States | 19741 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 |
sales@aladdinsci.com | United States | 52924 | 58 |
Shanghai Tauto Biotech Co., Ltd. | 021-51320588 |
tauto@tautobiotech.com | China | 3989 | 66 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 |
info@efebio.com | China | 9806 | 58 |
Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
sales@glpbio.cn | China | 6777 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11218 | 58 |
Chengdu Jiuding Chemical Technology Co., Ltd. - Song Bo | 18584079237 |
312074905@qq.com | China | 2505 | 58 |
Meng Cheng Technology (Shanghai) Co., LTD | 400-820-6829 |
sales@mitachieve.com | China | 8860 | 58 |
TargetMol Chemicals Inc. | 4008200310 |
marketing@tsbiochem.com | China | 24644 | 58 |
????B ?? ??:
??????????
METHOXYMELONAL
VINYL NEODECANOATE
TERT-BUTYL VINYL ETHER
ETHYL CYCLOHEXANEPROPIONATE
3-ETHOXYCARBONYL-5,6-DIHYDRO-2-METHYL-4H-PYRAN
VINYL N-OCTANOATE
BENZYL CAPRYLATE
CYCLOHEXYL VINYL ETHER
10-UNDECENOIC ACID VINYL ESTER
territrem B
4-HYDROXY-6-PHENYL-PYRAN-2-ONE
2-METHYL-5,6-DIHYDRO-4H-PYRAN-3-CARBOXYLIC ACID
ETHYL 6-KETO-7-OCTENOATE
veratryl acetate
ETHYL 3-ETHOXYBUT-2-ENOATE
5-(3-METHOXY-PHENYL)-PENTA-2,4-DIENOIC ACID
BENZYL 2-PROPYLACRYLATE 99