ChemicalBook >?? ???? >1-????-SN-????-3-?????

1-????-SN-????-3-?????

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?? ??:: 17364-16-8

???:: 1-????-SN-????-3-?????

???(??):: 1-????-SN-????-3-?????

???:: 1-PALMITOYL-SN-GLYCERO-3-PHOSPHOCHOLINE

???(??):: 1-PALMITOYL-2-HYDROXY-SN-GLYCERO-3-PHOSPHOCHOLINE;LYSO-PC;1-hexadecanoyl-sn-glycero-3-phosphocholine;LYSO-PPC;16:0 LYSO PC;Palmitoyl Lyso-phosphocholine;1-Pal PC;P-LYSO-PC;Choline Impurity 1;LysoFos Choline 16

CBNumber:: CB8672575

???:: C24H50NO7P

??? ??:: 495.63

MOL ??:: 17364-16-8.mol

MSDS ??:: SDS

?? ?? 157

1-????-SN-????-3-????? ??

???: 253 °C

?? ??: -20°C

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BRN: 5385682

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?? ? ???? ?? (GHS)

WGK ??	3
F ??????	10-21
HS ??	2923.20.2000

????(GHS):

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Danger

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??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H331	???? ???	?? ?? ?? ??	?? 3	??	P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H336	?? ?? ???? ??? ? ??	?????? ?? ??(1? ??);????	?? 3	??	P261, P271, P304+P340, P312,P403+P233, P405, P501
H351	?? ??? ??? ??? (????? ?? ???? ???? ???? ??? ?? ????? ??? ???? ??)	??? ??	?? 2	??	P201, P202, P281, P308+P313, P405,P501
H372	??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ???	?? ???? ?? - ?? ??	?? 1	??	P260, P264, P270, P314, P501
H412	??? ??? ?? ????? ???	?? ????? ?? - ??	?? 3		P273, P501

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P201	?? ? ?? ???? ?????.
P273	???? ???? ???.
P302+P352	??? ??? ??? ?? ????.
P308+P313	?? ?? ??? ???? ???? ??· ??? ????.

NFPA 704

	3
3		0

1-????-SN-????-3-????? C??? ??, ??, ??

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1-Palmitoyl-2-hydroxy-sn-glycero-3-PC is the ubiquitous lipid species generated following phospholipase A₂ (PLA₂) hydrolysis of phosphatidylcholine. It increases the production of reactive oxygen species (ROS) and decreases superoxide dismutase (SOD) and endothelial nitric oxide synthase (eNOS) protein levels and phosphorylation of ERK1/2 in human umbilical vein endothelial cells (HUVECs) when used at a concentration of 125 μM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC potentiates the secretion of IL-6, IL-1β, IL-12, and TNF-α in LPS-stimulated M1 macrophages, but has no effect on CD163, CD206, CD36, or IL-10 in LPS-stimulated M2 macrophages when used at concentrations of 0.3 and 1.0 μM. It increases TGF-β1 production and enhances Foxp3 protein levels in T_reg cells in isolated human peripheral blood when used at a concentration of 10 μM. 1-Palmitoyl-2-hydroxy-sn-glycero-3-PC enhances neutrophil function, bacterial clearance, and survival in mouse models of sepsis when administered at a dose of 10 mg/kg.

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White Solid

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A lipid biomarker for stable and unstable heart disease.

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