????????
|
|
???????? ??
- ???
- 273 °C (dec.)(lit.)
- ??
- -75.5 º (c=5, H2O)
- ?? ?
- 242.42°C (rough estimate)
- ??
- 1.3121 (rough estimate)
- ?? ??
- 610kg/m3
- ?? ??
- 4.5 (vs air)
- ???
- -75.5 ° (C=4, H2O)
- ?? ??
- Store below +30°C.
- ???
- H2O: 50 mg/mL
- ??? ??
- ?? ?? ??? ??
- ?? ?? (pKa)
- 1.82, 9.66(at 25℃)
- ??
- ???
- ??
- ?? ??
- ??????(pH)
- 5.5-6.5 (50g/l, H2O, 20℃)
- optical activity
- [α]25/D 75.6°, c = 1 in H2O
- ???
- 357.8g/L(20℃)
- Merck
- 14,4840
- BRN
- 471933
- InChIKey
- PMMYEEVYMWASQN-DMTCNVIQSA-N
- LogP
- -0.350 (est)
- CAS ??????
- 51-35-4(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
??? ?? | Xi,Xn | ||
---|---|---|---|
?? ???? ?? | 36/37/38-22 | ||
????? | 24/25-36/37/39-27-26 | ||
WGK ?? | 3 | ||
RTECS ?? | TW3586500 | ||
TSCA | Yes | ||
?? ?? | IRRITANT | ||
HS ?? | 29339990 |
???????? C??? ??, ??, ??
??
A non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.??? ??
White crystalline powder??
A natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.??
ChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.?? ??
In the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.
?? ??
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standardsPurification Methods
Crystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]???????? ?? ?? ? ???
???
?? ??
N-Boc-cis-4-Hydroxy-L-proline methyl ester
(R)-(-)-3-Pyrrolidinol hydrochloride
(2S,4S)-(-)-N-BOC-4-Diphenylphosphino-2-diphenylphosphinomethyl-pyrrolidine
tert-??2,5-???????[2.2.1]??-2-??????????
N-Boc-4-oxo-L-Proline methyl ester
Fmoc-L-????????
3-[[[(2S,4S)-4-Mercapto-1-(4-nitrobenzyloxy)carbonyl-2-pyrrolidinyl]carbonyl]amino]benzoic acid
1-Boc-2-???????-4-M…
2-???????,4-?????-,???(1:1),(2S,4R)-
BETONICINE
???-4-?????-1-(4-????????????)-L-???
N-CBZ-CIS-4-HYDROXY-D-PROLINE METHYL ESTER
1-????
1-????
???????? ?? ??
???( 991)?? ??
??? | ?? | ??? | ?? | ?? ? | ?? |
---|---|---|---|---|---|
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???????? ?? ??:
L-(-)-???
trans-4-Hydroxy-L-proline methyl ester hydrochloride
trans,trans-2,4-Undecadienal
trans-4-Hydroxy-D-proline
D-Proline
CHLOROPHOSPHONAZO III
N-Acetyl-L-Hydroxyproline
L-PROLINE-(4-3H(N))
L-(+)-Prolinol
L-Leucine
Methyl L-leucinate hydrochloride
cis-4-Hydroxy-L-proline
Boc-Hyp-OH
cis-4-Hydroxy-D-proline
BETONICINE
(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER,(2S,4R)-BOC 4-HYDROXYPROLINE METHYL ESTER
BOC-HYP(BZL)-OH
Fmoc-Hyp(tBu)-OH