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BROMOPRIDE

BROMOPRIDE ??? ???
?? ??:
4093-35-0
???:
BROMOPRIDE
???(??):
Emoril;Viadil;Praiden;Plesium;Opridan;Artomey;Emepride;val13081;BROMOPRID;VAL 13081
CBNumber:
CB8288660
???:
C14H22BrN3O2
??? ??:
344.25
MOL ??:
4093-35-0.mol

BROMOPRIDE ??

???
148-150?C
?? ?
435.8±45.0 °C(Predicted)
??
1.4132 (rough estimate)
???
1.6200 (estimate)
?? ??
2-8°C
???
?????(?? ???), DMSO(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
13.84±0.46(Predicted)
??
???? ?????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 20/21/22
????? 36
WGK ?? 3
RTECS ?? BZ3280000
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 ??? ???? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? GHS hazard pictograms P261, P271, P304+P340, P312
??????:
P280 ????/???/???/?????? ?????.
NFPA 704
0
3 0

BROMOPRIDE C??? ??, ??, ??

??

Bromopride is a dopamine D2 receptor antagonist (Ki = 14 nM). It binds to bovine anterior pituitary membranes with an IC50 value of 2.13 μM. Bromopride inhibits cholinesterase activity in vitro in rat plasma and striatum homogenate (IC50s = 67.8 and 38.4 μM, respectively). It increases serum prolactin levels in rats by 100% when used at a dose of 0.02 mol/kg. Bromopride (2.5 mg/kg) decreases locomotion and rearing in an open field test and impairs acquistion, but not retention, of a conditioned avoidance response in a two-way active conditioned avoidance test in rats.

??? ??

White Solid

BROMOPRIDE ?? ?? ? ???

???

?? ??


BROMOPRIDE ?? ??

???( 110)?? ??
??? ?? ??? ?? ?? ? ??
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BROMOPRIDE ?? ??:

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