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Se-Methylselenocysteine

Se-Methylselenocysteine ??? ???
?? ??:
26046-90-2
???:
Se-Methylselenocysteine
???(??):
SEMC;L-Se-Methylselenocysteine;SE-METHYLSELENO-L-CYSTEINE;MSeC;SeMSC;Se MSC;SeMCys;Se-MSC;METHYLSELENO-L-CYSTEINE;SE-METHYLSELENOCYSTEINE
CBNumber:
CB8265719
???:
C4H9NO2Se
??? ??:
182.08
MOL ??:
26046-90-2.mol

Se-Methylselenocysteine ??

???
177 °C(dec.)
?? ?
314.1±37.0 °C(Predicted)
?? ??
Keep in dark place,Inert atmosphere,2-8°C
???
DMSO(?? ???), ?(?? ???)
?? ?? (pKa)
2.17±0.10(Predicted)
??? ??
??
??
???? ?? ???
InChI
InChI=1S/C4H9NO2Se/c1-8-2-3(5)4(6)7/h3H,2,5H2,1H3,(H,6,7)/t3-/m0/s1
InChIKey
XDSSPSLGNGIIHP-VKHMYHEASA-N
SMILES
C(O)(=O)[C@H](C[Se]C)N
LogP
-0.043 (est)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T,N
?? ???? ?? 23/25-33-50/53
????? 20/21-28-45-60-61-28A
????(UN No.) UN 3283 6.1/PG 2
WGK ?? 3
F ?????? 10-23
HS ?? 29319090
????(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ?? ?? ???? ?? - ?? ?? ?? 2 ?? P260, P314, P501
H410 ??? ??? ?? ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P273 ???? ???? ???.
P314 ???? ??? ???? ??·??? ????.
P391 ???? ????.
P403+P233 ??? ??? ? ?? ?? ??? ???? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

Se-Methylselenocysteine C??? ??, ??, ??

??

Se-methyl selenocysteine (MSC) is a naturally occurring selenium compoundwith favourable pharmacokinetic properties andth high peroral bioavailability in humans. MSC is synthesized by plants such as garlic, astragalus, onions and broccoli. Se-methylselenocysteine has been proven to have a chemo-preventive property, which is shown by several authors via various cell culture models and animal models. It has also been shown to have anti-carcinogenic properties by inducing cell cycle arrest and apoptotic cell death. It is considered a pro-drug because the compound per se is not toxic unless it is metabolized by the enzymes Kynurenine aminotransferase 1 (KYAT1), Kynurenine aminotransferase 3 (KYAT3) and cystathionine γ-lyase (CTH). Of these, KYAT1 plays a vital role in MSC metabolism.

??? ??

white to slightly yellow powder

benefits

Se-methylselenocysteine (MSC) is a naturally occurring selenium compound with favorable pharmacokinetic properties and high peroral bioavailability in humans. MSC has been proven to have a chemo-preventive property, which several authors show via various cell culture models and animal models. It has also been shown to have anti-carcinogenic properties by inducing cell cycle arrest and apoptotic cell death. It is considered a pro-drug because the compound per se is not toxic unless it is metabolized by the enzymes Kynurenine aminotransferase 1 (KYAT1), Kynurenine aminotransferase 3 (KYAT3) and cystathionine γ-lyase (CTH). Of these, KYAT1 plays a vital role in MSC metabolism. KYAT1 is a PLP dependent enzyme whose main function is to cleave carbon-sulfur bonds. KYAT is a bi-functional enzyme that catalyzes transamination and β-elimination reactions with single substrates. KYAT1 metabolizes MSC into β-methylselenopyruvate (MSP) and methylselenol via transamination and β-elimination catalysis.

Se-Methylselenocysteine ?? ?? ? ???

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?? ??


Se-Methylselenocysteine ?? ??

???( 223)?? ??
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Se-Methylselenocysteine ?? ??:

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