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?? ??:: 417717-21-6

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???(??):: ???????f

???:: Lenvatinib Impurity f

???(??):: Lenvatinib Impurity f;Levatinib Impurity 11;Lenvatinib ImpurityFS-I;Lenvatinib Carboxylic Acid;4-(3-chloro-4-(3-cyclopropylureido)phenoxy)-7-methoxyquinoline-6-carboxylic acid;4-[3-Chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-6-quinolinecarboxylic acid;6-Quinolinecarboxylic acid, 4-[3-chloro-4-[[(cyclopropylamino)carbonyl]amino]phenoxy]-7-methoxy-

CBNumber:: CB73038993

???:: C21H18ClN3O5

??? ??:: 427.84

MOL ??:: 417717-21-6.mol

?? ?? 60

???????f ??

?? ?: 599.5±50.0 °C(Predicted)

??: 1.50±0.1 g/cm3(Predicted)

?? ?? (pKa): 2.74±0.30(Predicted)

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P264	?? ??? ?? ??? ????.
P264	?? ??? ?? ??? ????.
P270	? ??? ??? ??? ???, ???? ???? ???.
P271	?? ?? ??? ? ?? ???? ?????.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P304+P340	???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P330	?? ?????.
P332+P313	?? ??? ??? ???? ??· ??? ????.
P337+P313	?? ?? ??? ???? ???? ??· ??? ????.
P362	??? ??? ?? ?? ?? ?????
P403+P233	??? ??? ? ?? ?? ??? ???? ?????.
P405	???? ?????.
P501	...? ??? / ??? ?? ???.

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Desamino Hydroxy Lenvatinib serves as a reagent for the synthesis of urea derivatives containing nitrogenous aromatic ring compounds that functions as angiogenesis inhibitors for treatment of diseases. It is also a derivative compound of Lenvatinib (L329400) that serves as orally active inhibitor of multiple receptor tyrosine kinases including VEGF, FGF and SCF receptors.

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???	??	???	??	?? ?	??
Standardpharm Co. Ltd.	86-714-3992388	overseasales1@yongstandards.com	United States	14332	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29809	58
Arizest(Shanghai)Pharmatech Co., Ltd	+86-021-60753300	3652837972@qq.com	China	220	58
Moxin Chemicals	+8617320513646	mike@molcoo.com	China	9695	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
QUALITY CONTROL SOLUTIONS LTD.	0755-66853366; 13670046396	ORDERS@QCSRM.COM	China	24342	58
Chengdu Feibo Pharm Technology Co., Ltd	+86 028-84641798 15982321820	abby@arkpharm.com	China	10922	58
Adamas Reagent, Ltd.	400-6009262 16621234537	chenyj@titansci.com	China	14103	59
S.Z. PhyStandard Bio-Tech. Co., Ltd.	0755-4000505016 13380397412	3001272453@qq.com	China	5047	50
Beijing Comparison Pharmaceutical Technology Co., Ltd	010-010-52878169 15801002657	sales@bjcomparison.com	China	4816	58

???????f ?? ??:

Lenvatinib 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide Lenvatinib Impurity e Lenvatinib Impurity g Lenvatinib Impurity 22 Lenvatinib Impurity 23 Lenvatinib Impurity 25 Lenvatinib Impurity 7 Descyclopropyl Lenvatinib Lenvatinib Impurity 21 Lenvatinib Impurity 4 4-(4-amino-3-chlorophenoxy)-7-methoxyquinoline-6-carboxamide Lenvatinib Impurity 30 Lenvatinib Impurity 24 4,4'-[Carbonylbis[imino(3-chloro-4,1-phenylene)oxy]]bis[7-methoxy-6-quinolinecarboxamide] Lenvatinib Impurity 27 Lenvatinib Impurity 10 Lenvatinib Impurity 2

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