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PD153035???

PD153035???
PD153035??? ??? ???
?? ??:
153436-54-5
???:
PD153035???
???(??):
PD153035???
???:
PD 153035 HYDROCHLORIDE
???(??):
PD153035HCl;AG-1517 HCl;Zinc00600292;PD 153035(AG-1517);PD 153035 HYDROCHLORIDE;PD153035;ZM 252868; AG 1517;PD153035 (Tyrphostin AG 1517);PD153035;AG1517;PD-153035;AG-1517;4-Pyrimidinol,2-methoxy-10-methyl-;4-(3-Bromo-benzyl)-6,7-dimethoxy-quinazoline
CBNumber:
CB7249204
???:
C16H14BrN3O2
??? ??:
360.21
MOL ??:
153436-54-5.mol
MSDS ??:
SDS

PD153035??? ??

???
189-190 °C
?? ?
472.1±45.0 °C(Predicted)
??
1.499±0.06 g/cm3(Predicted)
?? ??
Keep in dark place,Inert atmosphere,2-8°C
???
DMSO? ?????(?? 5mg/ml).
?? ?? (pKa)
5.55±0.30(Predicted)
??? ??
?? ?? ??? ??.
??
?? ?? ???
???
??? ?? ?????? 1? ?? ??????. DMSO? ???? -20°?? ?? 3?? ?? ??? ? ????.
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? GHS hazard pictograms P261, P271, P304+P340, P312
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P280 ????/???/???/?????? ?????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
3 0

PD153035??? C??? ??, ??, ??

??? ??

Yellowish solid

??

PD153035 is an inhibitor of EGFR, competitive with ATP. EGF Receptor: IC50 = 25 pM (Ki = 6 pM).

??

ChEBI: A member of the class of quinazolines carrying a 3-bromophenylamino substituent at position 4 and two methoxy substituents at positions 6 and 7.

???? ??

An extremely potent inhibitor of epidermal growth factor (EGF) receptor tyrosine kinase, with an IC 50 of 25 pM. Inhibits other purified tyrosine kinases only at micromolar or higher concentrations.

PD153035??? ?? ?? ? ???

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PD153035??? ?? ??

???( 151)?? ??
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PD153035??? ?? ??:

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