Raubasine
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Raubasine ??
- ???
- 258°C (rough estimate)
- ?? ?
- 486.04°C (rough estimate)
- ??
- D20 -60° (c = 0.5 in chloroform); D20 -45° (c = 0.5 in pyridine); D20 -39° (c = 0.25 in methanol)
- ??
- 1.1823 (rough estimate)
- ???
- 1.6500 (estimate)
- ?? ??
- 2-8°C
- ???
- ?????(?? ???), ???(?? ???, ??)
- ??? ??
- ??
- ??? ??
- ??? ??
- ?? ?? (pKa)
- pK1:10.55(+1) (25°C)
- ??
- ?? ??
- optical activity
- [α]/D -65±3°, c = 1 in chloroform
- ???
- ?? ???
- BRN
- 97268
- LogP
- 2.880 (est)
- NIST
- Ajmalicine(483-04-5)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 25-22 | ||
| ????? | 22-45 | ||
| ????(UN No.) | 1544 | ||
| WGK ?? | 3 | ||
| RTECS ?? | AX7875000 | ||
| ?? ?? | 6.1(b) | ||
| ???? | III |
Raubasine C??? ??, ??, ??
??
Vinca rosea L. yields this alkaloid which crystallizes as colourless needles from MeOH. The base is laevorotatory having a specific rotation of [α]D_620 (MeOH) and forms a crystalline hydrochloride, m.p. 281-3°e. The structure given above has been elucidated from chemical and spectroscopic data.??
Antihypertensive, anti-ischemic (cerebral and peripheral)Purification Methods
It crystallises from MeOH, EtOH or EtOAc. [Beilstein 27 III/IV 7927.]?? ??
Janot, Le Men, Cornpt. Rend., 243, 1786 (1956) Shamma, Moss, J. Arner. Chern. Soc., 83, 5038 (1961) Abdurakhsimova, Yuldashev, Yunusov, Khirn. Prir. Soedin., 1,224 (1965)Raubasine ?? ?? ? ???
???
?? ??
Raubasine ?? ??
???( 190)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
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Raubasine ?? ??:
???? ?? ?????? ?????? ????? ?? ?????? ??? ???? ?? ??? ??? ?? ?? ?????(?? ????)
Methyl
almitrine-raubasine
Methyl 4-piperidineacetate
1-METHYL-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE
RAUBASINE HYDROCHLORIDE,δ-Yohimbine hydrochloride, Raubasine hydrochloride
1,2,3,4-TETRAHYDRO-9H-PYRIDO[3,4-B]INDOLE
4-Piperidineethanol
(1-Methyl-piperidin-4-yl)-acetaldehyde
2,4-Dimethylpiperidine
AJMALINE