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SCUTELLAREIN

SCUTELLAREIN ??? ???
?? ??:
529-53-3
???:
SCUTELLAREIN
???(??):
SCUTELLAREIN;Scutillarein;Scutellartln;isocarthamidin;High baicalein;Scutellarein-RM;6-HYDROXYAPIGENIN;SCUTELLAREIN WITH HPLC;SCUTELLAREIN, 98.0% BY HPLC;5,6,7,4'-TETRAHYDROXYFLAVONE
CBNumber:
CB6402688
???:
C15H10O6
??? ??:
286.24
MOL ??:
529-53-3.mol
MSDS ??:
SDS

SCUTELLAREIN ??

???
330°C
?? ?
642.9±55.0 °C(Predicted)
??
1.654±0.06 g/cm3(Predicted)
?? ??
Sealed in dry,2-8°C
???
DMSO: ??? 1mg/mL, ??, ???
?? ?? (pKa)
6.34±0.40(Predicted)
??? ??
??
??
???
InChIKey
JVXZRQGOGOXCEC-UHFFFAOYSA-N
LogP
2.540 (est)

??

????? 24/25
WGK ?? 3
HS ?? 29329990

SCUTELLAREIN C??? ??, ??, ??

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Scutellarein is a flavone that has been isolated from S. baicalensis and has antioxidant, enzyme inhibitory, anti-inflammatory, and antiproliferative biological activities. It has antioxidant activity in a total reactive antioxidant potential (TRAP) assay when used at a concentration of 1 μg/ml. Scutellarein inhibits sucrose hydrolysis by rat intestinal α-glucosidase and ATPase activity of the severe acute respiratory syndrome (SARS) coronavirus helicase nsP13 (IC50s = 12 and 0.86 μM, respectively). It decreases nitric oxide (NO) release and mRNA expression of inducible NO synthase (iNOS) and TNF-α induced by LPS in RAW 264.7 macrophages when used at a concentration of 50 μM. In vivo, scutellarein (0.5 μg/g) decreases tumor weight and volume in an HT-1080 human fibrosarcoma mouse xenograft model.

??? ??

Yellow solid

??

Scutellarein is a flavonoid that can be found in Scutellaria lateriflora. Scutellarein is a hydrolysis product of Scutellarein (S201900), its glucuronide conjugated analogue.

??

ChEBI: Flavone substituted with hydroxy groups at C-4', -5, -6 and -7.

SCUTELLAREIN ?? ?? ? ???

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SCUTELLAREIN ?? ??

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