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25122-46-7
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Clobetasol propionate
???(??):
CLOBETASOLE PROPIONATE;Olux;Clobex;Temovate;CLOBETASOL-17-PROPIONATE;Psorex;Olux-E;cgp9555;GR-2/92;Karison
CBNumber:
CB6274337
???:
C25H32ClFO5
??? ??:
466.97
MOL ??:
25122-46-7.mol

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195.5-1970C
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D +103.8° (c = 1.04 in dioxane)
?? ?
569.0±50.0 °C(Predicted)
??
1.1653 (estimate)
?? ??
Keep in dark place,Sealed in dry,2-8°C
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??? ?? ?? ???, ????? ? ??, ????? ?? ?? ????(96%).
?? ?? (pKa)
12.88±0.70(Predicted)
??? ??
Solid
??
White to off-white
InChIKey
CBGUOGMQLZIXBE-XGQKBEPLSA-N
SMILES
O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS ??????
25122-46-7(CAS DataBase Reference)
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi,T
?? ???? ?? 36/37/38-62-53-48/20/21-61
????? 26-36-45-36/37-53
WGK ?? 2
RTECS ?? TU3725000
HS ?? 29372290
????(GHS): GHS hazard pictograms
?? ?: Danger
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?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H373 ??? ?? ?? ???? ??(??, ??? ?? ??? ?? ??? ??)? ??? ??? ? ?? ?? ???? ?? - ?? ?? ?? 2 ?? P260, P314, P501
H413 ??? ??? ?? ????? ??? ??? ?? ?? ????? ?? - ?? ?? 4
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P201 ?? ? ?? ???? ?????.
P273 ???? ???? ???.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
0
2 0

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White or almost white, crystalline powder.

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Topical corticosteroid. Glucocorticoid; anti-inflammatory.
Clobetasol Propionate
Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Indications

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

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ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.

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