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GNF 5837

GNF 5837 ??? ???
?? ??:
1033769-28-6
???:
GNF 5837
???(??):
CS-997;GNF 5837;GNF-5837, >97%;GNF-5837, >=98%;GNF5837; GNF 5837;GNF 5837 USP/EP/BP;Trk Inhibitor III, GNF-5837;Trk Inhibitor III, GNF-5837 - CAS 1033769-28-6 - Calbiochem;(Z)-1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-;1-(3-((3-((1H-Pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)amino)-4-methylphenyl)-3-(2-fluoro-5-(trifluoromethyl)phenyl)urea
CBNumber:
CB62667487
???:
C28H21F4N5O2
??? ??:
535.49
MOL ??:
1033769-28-6.mol
MSDS ??:
SDS

GNF 5837 ??

???
>228°C (dec.)
?? ?
616.0±55.0 °C(Predicted)
??
1.497±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMSO: ???5mg/mL, ??(??)
?? ?? (pKa)
12.16±0.20(Predicted)
??? ??
??
??
????? ?????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 36/37/39
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321 (…) ??? ???.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P362 ??? ??? ?? ?? ?? ?????
NFPA 704
0
2 0

GNF 5837 C??? ??, ??, ??

??

GNF 5837 is a potent pan-Trk inhibitor which has selectivity for tropomyosin-receptor-kinase (Trk).

Biochem/physiol Actions

GNF-5837 is an orally bioavailable Trk inhibitor (IC50 = 8 and 12 nM for TrkA and TrkB, respectively). GNF-5837 inhibits growth of Ba/F3 cells expressing Tel-Trl fusions. IC50 values for growth inhibition are Tel-TrkA = 11 nM, Tel-TrkB = 9 nM and Tel-TrkC = 7 nM.

GNF 5837 ?? ?? ? ???

???

??????,4-BROMO-2-NITRO-,?????? (4-???-2-???-??)-???? 4-???-1-????-2-????? ???-2-?????????

?? ??

GNF 5837 ?? ??

???( 106)?? ??
??? ?? ??? ?? ?? ? ??
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GNF 5837 ?? ??:

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