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Dihydroergotoxine mesylate

Dihydroergotoxine mesylate ??? ???
?? ??:
8067-24-1
???:
Dihydroergotoxine mesylate
???(??):
ERGOLOID MESYLATES;hydergine;circanol;Epos;ergoloid mesylate;cck179;Decril;Trigot;Inorter;Dacoren
CBNumber:
CB6226235
???:
C20H29N3O5S
??? ??:
423.53
MOL ??:
8067-24-1.mol

Dihydroergotoxine mesylate ??

?? ??
Store at RT
???
DMSO: Slightly Soluble; Methanol: 1 mg/ml
??? ??
Solid
??
White to off-white
InChIKey
ONYMVHQTXOEAOV-TZWRWDCZNA-N
SMILES
C12C3=CC=CC=1[C@@]1([H])C[C@H](CN(C)[C@]1([H])CC2=CN3)C(=O)N[C@@H](C)CO.S(=O)(=O)(O)C |&1:6,9,13,22,r|
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  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 60
????? 53-36/37/39-45
????(UN No.) 1544
RTECS ?? KE8800000
?? ?? 6.1(b)
???? III
HS ?? 3003490000
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
NFPA 704
0
4 0

Dihydroergotoxine mesylate C??? ??, ??, ??

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Ergoloid, also known as dihydroergotoxine mesylate, is a mixture of the ergot alkaloids dihydroergocornine, dihydroergocrystine, and dihydroergocryptine. It blocks reflex vasodilation and vasoconstriction induced by norepinephrine in dogs when injected into the kidney at a dose of 0.15 mg. Ergoloid blocks norepinephrine-induced cAMP production in rat brain cortical homogenates ex vivo in a dose-dependent manner. It also acts as an erectogenic agent in rats. Formulations containing ergoloid have been used in the treatment of migraine headaches and vascular dementias.

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Cognition adjuvant. Dihydroergotoxine mesylate binds with high affinity to GABAA receptor Cl- channel. Interacts with central dopaminergic, serotonergic and adrenergic (a1) receptors. Exhibits antirproliferative activity in vitro. Displays cognition-enhancing, anticonvulsant and sedative activity in vivo. Dihydroergotoxine mesylate is a substrate of GABA Receptor.

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ChEBI: Dihydroergotoxine mesylate is a mixture of hydrogenated ergot alkaloids consisting of the methanesulfonic acid salts of dihydroergocornine (R = CHMe2), dihydroergocristine (R = CH2Ph), and alpha- and beta-dihydroer ocryptine (R = CH2CHMe2 and CH(Me)Et, respectively). It is used for the symptomatic treatment of mild to moderate dementia in the elderly, although its value is not established.

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Dihydroergotoxine mesylate is a complex of closely related alkaloid salts. Binds with high affinity to the GABAA receptor Cl- channel, producing an allosteric interaction with the benzodiazepine site. Also interacts with central dopaminergic, serotonergic and adrenergic (α1) receptors. Displays antiproliferative activity in vitro (IC50 = 18 - 38 μM in prostate cancer cells) and exhibits cognition-enhancing, anticonvulsant and sedative activity in vivo. 

Dihydroergotoxine mesylate ?? ?? ? ???

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Dihydroergotoxine mesylate ?? ??

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Dihydroergotoxine mesylate ?? ??:

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