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?? ??:
782500-75-8
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???(??):
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???:
Albiglutide
???(??):
Albugon;Gsk 716155;albiglutide;Naliglutide;Unii-5E7U48495e;Albiglutide Fragment;Albiglutide(Acetate);Albiglutide USP/EP/BP;Research Grade Albiglutide;Albiglutide Eperzan Tanzeum
CBNumber:
CB61518490
???:
C148H223N39O46
??? ??:
3284.58792
MOL ??:
782500-75-8.mol

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Store at -20°C
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Water: 100 mg/mL (30.45 mM);
InChIKey
OGWAVGNOAMXIIM-VTAHJYCESA-N

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?? ?? ??? 782500-75-8(Hazardous Substances Data)

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Albiglutide (also known as naliglutide, GSK 716155) isa sequential dimer of GLP-1(7–36)(Ala8→Gly) covalentlylinked to modified human serum albumin (i.e., it is a “fusionprotein” with modified HSA). This molecule is currentlywell into phase III clinical trials. Although albiglutide,if marketed (Syncria, GlaxoSmithKline), will—likeexenatide—be administered by injection, the half-life andduration of 6 to 7 days would allow for weekly administration.

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This GLP-1 agonist and anti-diabetic drug (MW = 72.9 kDa; CAS 782500- 75-8), marketed as Eperzan? and Tanzeum?, by GlaxoSmithKline (GSK) is a dipeptidyl peptidase-4-resistant glucagon-like peptide-1 dimer fused to human albumin. Albiglutide has a half-life of 4-7 days, commending it for biweekly or weekly administration in the treatment of Type 2 diabetes. The half-life is considerably longer than exenatide (Byetta?) and liraglutide (Victoza?).

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