3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE C??? ??, ??, ??

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Methyl-3,4-dephostatin has been used as:

• an inhibitor for methyltransferases
• a kinase-related inhibitor for human transglutaminase
• a cysteine binding compound for screening its effect on C-terminal domain (CTD) of human immunodeficiency virus (HIV-1) capsid protein

Biochem/physiol Actions

Methyl-3,4-dephostatin is a tyrphostin-related compound isolated from Streptomyces MJ742-NF5 strain. It favors nerve growth factor-based neurite formation in pheochromocytoma PC12 cells. Being a stable analog of the nitrosoaniline dephostatin, it can mimic phosphotyrosine substrate for Tyrosyl-DNA phosphodiesterase I (TdpI).

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3,4-DIHYDROXY-N-METHYL-N-NITROSOANILINE ?? ??

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Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80

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