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POLYGODIAL

POLYGODIAL ??? ???
?? ??:
6754-20-7
???:
POLYGODIAL
???(??):
Poligodial;POLYGODIAL;(-)-Tadeonal;Polygodial (Tadeonal);Drim-7-ene-11,12-dial;Polygodial, TRPA1 agonist;1,4,4A,5,6,7,8,8A-Octahydro-5,5,8A-trimethyl-1,2-naphthalenedicarboxaldehyde;(1R,4aS,8aS)-1,4,4a,5,6,7,8,8a-Octahydro-5,5,8a-trimethyl-1,2-naphthalenedicarboxaldehyde;1,2-Naphthalenedicarboxaldehyde, 1alpha,4,4aalpha,5,6,7,8,8A-octahydro-5,5,8abata-trimethyl-;1,2-Naphthalenedicarboxaldehyde, 1,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethyl-, (1R,4aS,8aS)-
CBNumber:
CB5284348
???:
C15H22O2
??? ??:
234.33
MOL ??:
6754-20-7.mol
MSDS ??:
SDS

POLYGODIAL ??

???
57° (Barnes, Loder)
??
D24 -131° (c = 0.96 in ethanol)
?? ?
330.7±35.0 °C(Predicted)
??
1.084±0.06 g/cm3(Predicted)
RTECS ??
QJ2850000
?? ??
-20°C
???
DMSO: ???20mg/mL, ??
??? ??
??
??
???? ????
???
??? ?? ?????? 2? ?? ??????. DMSO ?? ??? ??? -20°C?? ?? 2?? ?? ??? ? ????.
LogP
3.522 (est)

??

?? ???? ?? 52/53
????? 61
WGK ?? 3

POLYGODIAL C??? ??, ??, ??

??

Polygodial is a naturally occurring antifungal and antinociceptive.

Biochem/physiol Actions

Polygodial is a selective activator of Transient Receptor Potential Anykrin 1 (TRPA1) channels. Initially painful, polygodial acts as an analgesic by desensitizing sensory neuron. Polygodial also has broad antifungal properties, and is cytotoxic against bacteria and algae.

POLYGODIAL ?? ?? ? ???

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POLYGODIAL ?? ??

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