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ATB 346

ATB 346 ??? ???
?? ??:
1226895-20-0
???:
ATB 346
???(??):
ATB 346;ABT-346;CS-1282;Otenaproxesul;ATB-346, >=98%;ATB346;ATB 346;ATB 346,1226895-20-0;4-CARBAMOTHIOYLPHENYL 2-(6-METHOXYNAPHTHALEN-2-YL)PROPANOATE;2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester;2-Naphthaleneacetic acid, 6-methoxy-α-methyl-, 4-(aminothioxomethyl)phenyl ester
CBNumber:
CB52627347
???:
C21H19NO3S
??? ??:
365.45
MOL ??:
1226895-20-0.mol

ATB 346 ??

?? ?
561.4±60.0 °C(Predicted)
??
1.261±0.06 g/cm3(Predicted)
?? ??
Store at -20°C
???
insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO
??? ??
??
??? ??
??? ??
?? ?? (pKa)
12.37±0.29(Predicted)
??
Light yellow to yellow
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P272 ??? ??? ??? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P333+P313 ????? ?? ??? ???? ???? ??·??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P363 ?? ??? ??? ??? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

ATB 346 C??? ??, ??, ??

??

ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen . It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 μM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 μmol/kg. ATB-346 (30 μmol/kg) improves motor function in a mouse model of spinal cord injury.

ATB 346 ?? ?? ? ???

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?? ??


ATB 346 ?? ??

???( 91)?? ??
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ATB 346 ?? ??:

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