ChemicalBook >?? ???? >ATB 346
ATB 346
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ATB 346 ??
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- 561.4±60.0 °C(Predicted)
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- 1.261±0.06 g/cm3(Predicted)
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- Store at -20°C
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- insoluble in EtOH; insoluble in H2O; ≥18.27 mg/mL in DMSO
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- ?? ?? (pKa)
- 12.37±0.29(Predicted)
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- Light yellow to yellow
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ATB 346 C??? ??, ??, ??
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ATB-346 is a non-steroidal anti-inflammatory drug (NSAID) that releases hydrogen sulfide (H2S) and a derivative of naproxen . It inhibits the proliferation of, and induces apoptosis in, A375 melanoma cells when used at a concentration of 100 μM. ATB-346 decreases prostaglandin E2 (PGE2) production in inflammatory exudates, reduces paw edema, and increases plasma levels of sulfide in a mouse model of zymosan-induced arthritis. It reduces the size of acetic acid-induced gastric ulcers in mice when administered at a dose of 60 μmol/kg. ATB-346 (30 μmol/kg) improves motor function in a mouse model of spinal cord injury.ATB 346 ?? ?? ? ???
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