GSK2636771
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GSK2636771 ??
- ???
- >225°C (dec.)
- ?? ?
- 641.3±55.0 °C(Predicted)
- ??
- 1.38
- ?? ??
- -20°C Freezer
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- -2.70±0.30(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ?? ??
- InChI
- InChI=1S/C22H22F3N3O3/c1-13-15(4-3-5-18(13)22(23,24)25)12-28-14(2)26-20-17(21(29)30)10-16(11-19(20)28)27-6-8-31-9-7-27/h3-5,10-11H,6-9,12H2,1-2H3,(H,29,30)
- InChIKey
- XTKLTGBKIDQGQL-UHFFFAOYSA-N
- SMILES
- C1(C)N(CC2=CC=CC(C(F)(F)F)=C2C)C2=CC(N3CCOCC3)=CC(C(O)=O)=C2N=1
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
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GSK2636771 C??? ??, ??, ??
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GSK2636771 is a potent, orally bioavailable, adenosine triphosphate-competitive, selective inhibitor of PI3Kβ with an apparent Ki value of 0.89 nmol/L (IC50 = 5.2 nmol/L), >900-fold selectivity over p110α and p110γ, and >10-fold selectivity over p110δ isoforms, while sparing other PI3K superfamily kinases[1-2].??
GSK2636771 is a potent, orally bioavailable, PI3Kβ-selective inhibitor, sensitive to PTEN null cell lines.GSK2636771 ?? ?? ? ???
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GSK2636771 ?? ??
???( 154)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 |
info@chuchangbiotech.com | China | 202 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 |
sales@capot.com | China | 29730 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33025 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29865 | 58 |
| Changzhou PBpharmaceutical R&D Co.,Ltd | 0519-83990708 |
info@pbpharm.com | CHINA | 498 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 |
linda@hubeijusheng.com | CHINA | 22963 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39894 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 |
sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22787 | 58 |
GSK2636771 ?? ??:
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