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6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE

6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE ??? ???
?? ??:
181468-88-2
???:
6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE
???(??):
PD 160170;6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE;8-Quinolinamine, 6-[[2-(1-methylethyl)phenyl]sulfonyl]-5-nitro-
CBNumber:
CB4842172
???:
C18H17N3O4S
??? ??:
371.41
MOL ??:
181468-88-2.mol

6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE ??

?? ?
646.6±55.0 °C(Predicted)
??
1.379±0.06 g/cm3(Predicted)
?? ??
Store at RT
???
Soluble to 100 mM in DMSO
??? ??
??
?? ?? (pKa)
-1.16±0.12(Predicted)

??

6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE C??? ??, ??, ??

???? ??

Potent, selective non-peptidic neuropeptide Y 1 receptor antagonist (K i = 48 nM); selective over Y 2 and Y 5 receptors (K i > 10 μ M). Antagonizes NPY-mediated inhibition of cAMP accumulation in SK-N-MC cells (IC 50 = 8.2 nM).

6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE ?? ?? ? ???

???

?? ??


6-[[2-(1-METHYLETHYL)PHENYL]]SULFONYL-5-NITRO-8-QUINOLINAMINE ?? ??

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