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102-05-6
???:
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???(??):
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Dibemethine
???(??):
DI;DBMA;L-566;L 566;AI3-26795;Dibemetina;DIBEMETHINE;Dibemethinum;METHYL DIBENZYLAMINE;DIBENZYL METHYL AMINE
CBNumber:
CB3842559
???:
C15H17N
??? ??:
211.3
MOL ??:
102-05-6.mol

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???
50 °C
?? ?
304-305 °C(Press: 765.5 Torr)
??
0.996 g/cm3(Temp: 22 °C)
?? ??
Sealed in dry,Room Temperature
?? ?? (pKa)
7.85±0.50(Predicted)
EPA
Benzenemethanamine, N-methyl-N-(phenylmethyl)- (102-05-6)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
H400 ????? ?? ??? ?? ????? ?? - ?? ?? 1 ?? GHS hazard pictograms P273, P391, P501
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P285 ??? ? ?? ?? ???? ??? ???? ?????
P301+P310 ???? ?? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P341 ???? ??,??? ??? ?? ??? ??? ??? ?? ??? ??? ???? ?? ??? ??? ??? ?
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P342+P311 ??? ??? ???? ????(??)? ??? ????.
P362 ??? ??? ?? ?? ?? ?????
P391 ???? ????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.

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Dibemethine is active against chloroquinone-resistant Plasmodium falciparum and inhibit chloroquine transport via the P. falciparum chloroquine-resistance transporter (PfCRT).

Synthesis Reference(s)

Journal of the American Chemical Society, 95, p. 3038, 1973 DOI: 10.1021/ja00790a064
Tetrahedron Letters, 20, p. 3395, 1979 DOI: 10.1016/S0040-4039(01)95418-8

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