??-???????????
|
|
??-??????????? ??
- ???
- 86-89 °C (lit.)
- ?? ?
- 125 °C (lit.)
- ??
- 0.87 g/mL at 20 °C(lit.)
- ???
- 60-710Pa at 25℃
- ???
- n
20/D 1.46
- ???
- 73 °F
- ?? ??
- Store below +30°C.
- ???
- very sol nearly all common organic solvents such as THF, methylene chloride, and DMF.
- ??? ??
- ?? ??
- Specific Gravity
- 1.225
- ??
- ???
- ???
- ?????? ?? ?????? ?????. ?? ???.
- ??
- Moisture Sensitive
- Hydrolytic Sensitivity
- 7: reacts slowly with moisture/water
- BRN
- 505999
- ?? ??
- ACGIH: TWA 20 ppm
OSHA: Ceiling 300 ppm; TWA 200 ppm
NIOSH: IDLH 500 ppm; TWA 100 ppm(375 mg/m3); STEL 150 ppm(560 mg/m3)
- InChIKey
- BCNZYOJHNLTNEZ-UHFFFAOYSA-N
- LogP
- 2.5 at 20℃
- CAS ??????
- 18162-48-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
??? ?? | C,F,T,Xn | ||
---|---|---|---|
?? ???? ?? | 22-35-40-34-10-19-11-67-65-63-48/20-20/21/22-45-23/24/25-37-36/37/38 | ||
????? | 26-36/37/39-46-62-45-25-16-28-27-33-29-53-36/37 | ||
????(UN No.) | UN 2925 4.1/PG 2 | ||
WGK ?? | 2 | ||
RTECS ?? | VV2000000 | ||
F ?????? | 10-21 | ||
?? ?? ?? | Flammable/Corrosive/Moisture Sensitive | ||
TSCA | Yes | ||
?? ?? | 4.1 | ||
???? | III | ||
HS ?? | 29310095 | ||
?? | mouse,LDLo,intraperitoneal,1gm/kg (1000mg/kg),IMMUNOLOGICAL INCLUDING ALLERGIC: DECREASED IMMUNE RESPONSE,Personal Communication from G.D. Stoner, Dept. of Community Medicine, School of Medicine, Univ. of California, La Jolla, CA 92037, May 25, 1975Vol. 27MAY1975, | ||
???? ?? | 97-3-163 |
??-??????????? C??? ??, ??, ??
??? ??
tert-Butyldimethylsilyl chloride is a colorless or white solid that is soluble in many organic solvents but reacts with water and alcohols.It is an organosilicon compound that can be used as a versatile protecting reagent for alcohols, amines, amides, and various carboxylic acids.?? ??
tert-butyldimethylsilyl chloride (TBSCI) was synthesized by the reaction of tert-butyllithium with dichlorodimethylsilane.The pentane solution of dichlorodimethylsilane was cooled to 0°C, and the pentane solution of tert-butyllithium was added dropwise with stirring under nitrogen. The temperature was maintained at 0 °C, stirred for 1.5 h and then heated to 25 °C, and the reaction was continued for 48 h. Distillation, collect 125 ℃ (97.5kPa) fractions, stand to solidify, and obtain tert-butyldimethylsilyl chloride. Yield 70%.
?? ??
Tert-butyldimethylsilyl chloride is a sterically hindered organosilicon protective agent, which is widely used in the synthesis of original drugs. It is used as a protective group for hydroxyl in the synthesis of ribonucleosides, and is also an oxidant and decyanide.t-Butyldimethylchlorosilane is useful as an anion trapping reagent. For example, TBDMSCl was found to be an efficient trap of the lithio α-phenylthiocyclopropane anion.When dichlorothiophene was treated with 2 equiv of n-butyllithium followed by 2 equiv of TBDMSCl the di-TBDMS-thiophene was isolated. The lithium anions of primary (eq 1) and secondary (eq 2) nitriles were trapped with TBDMSCl to give C,N-disilyl- and Nsilylketenimines in excellent yields.

Silyl stannanes have been prepared by trapping tin anions with TBDMSCl or other silyl chlorides. Alkynes treated with silyl stannanes and catalytic tetrakis(triphenylphosphine)palladium(0) give cis-silyl stannylalkenes in good yields.
??
ChEBI: Tert-butyldimethylsilyl chloride is a silyl chloride consisting of a central silicon atom covalently bound to one chloro, one tert-butyl and two methyl groups. tert-Butyldimethylsilyl chloride is a derivatisation agent used in gas chromatography/mass spectrometry applications. It has a role as a chromatographic reagent.?? ??
tert-Butyldimethylsilyl chloride reacts with alcohols in the presence of base to give tert-butyldimethylsilyl ethers:(Me3C)Me2SiCl + ROH → (Me3C)Me2SiOR + HCl
These silyl ethers hydrolyze much more slowly than the trimethylsilyl ethers.
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Moderately toxic.Purification Methods
Fractionally distil it at atmospheric pressure. [Sommer & Tyler J Am Chem Soc 76 1030 1954, Corey & Venkateswarlu J Am Chem Soc 94 6190 1972, Beilstein 4 IV 4076.]??-??????????? ?? ?? ? ???
???
?? ??
??-?????????(MAP)
(3R(1'R,4R))-(+)-4-????-3-(1-(T-??????????)ETH)-2- ?????
2-???-4-?????-??-L-????????
Calcipotriene
Trifluoromethanesulfonic acid tert-butyldimethylsilyl ester
2-CYANOPYRIDINE-4-CARBOXALDEHYDE
4-Mercaptophenylboronic acid
Montelukast
4-(HYDROXYMETHYL)PICOLINITRILE
5-(AMINOMETHYL)-1-METHYLPYRROLIDIN-2-ONE
?????
??(T-????????)??
Tert-Butyl N-(3-[(Tert-Butyldimethylsilyl)Oxy]-2-Oxopropyl)Carbamate
5-(TERT-?????????)-1-???
(3-BROMOPROPOXY)-TERT-BUTYLDIMETHYLSILANE
2-(tert-???????)???
??-??????????? ?? ??
???( 819)?? ??
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