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?? ???? >5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ??? ???
?? ??:
1584121-99-2
???:
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione
???(??):
IT901;IT 901,IT901;IT 901;IT901;IT-901;1584121-99-2;5-[(2,4-dimethoxynaphthalen-1-yl)methylidene]-2-sulfanylidene-1,3-diazinane-4,6-dione;5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione;5-[(2,4-Dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione;4,6(1H,5H)-Pyrimidinedione, 5-[(2,4-dimethoxy-1-naphthalenyl)methylene]dihydro-2-thioxo-
CBNumber:
CB33364216
???:
C17H14N2O4S
??? ??:
342.37
MOL ??:
1584121-99-2.mol
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ??
??
1.43±0.1 g/cm3(Predicted)
?? ??
Store at -20°C
???
DMF:33.0(Max Conc. mg/mL);96.39(Max Conc. mM) DMSO:33.0(Max Conc. mg/mL);96.39(Max Conc. mM) DMSO:PBS (pH 7.2) (1:6):0.14(Max Conc. mg/mL);0.41(Max Conc. mM)
??? ??
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?? ?? (pKa)
4.68±0.20(Predicted)
??
Orange to red
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5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione C??? ??, ??, ??
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IT 901 is a bioactive naphthalenethiobarbiturate derivative that potently inhibits the NF-κB subunit c-?Rel. IT 901 also revealed antitumor properties in vitro and in vivo.
5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ?? ?? ? ???
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5-((2,4-dimethoxynaphthalen-1-yl)methylene)-2-thioxodihydropyrimidine-4,6(1H,5H)-dione ?? ??
???( 47)?? ??
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