beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate
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beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate ??
- ???
- 128-130 °C
- ??
- 24.4 º (c=1, pyridine)
- ?? ?
- 621.0±55.0 °C(Predicted)
- ??
- 1.35±0.1 g/cm3(Predicted)
- ???
- 24 ° (C=1, Pyridine)
- ?? ??
- Sealed in dry,Room Temperature
- ???
- ?????(?? ???), ???????(?? ???), ???(?? ???, ?????),
- ??? ??
- ??
- ??
- ???? ?? ??? ?? ??? ? ??
- optical activity
- [α]20/D +24.3°, c = 1 in pyridine
- BRN
- 100243
- InChIKey
- GCZABPLTDYVJMP-CBUXHAPBSA-N
- SMILES
- C(OC)(=O)C1=CC=CC=C1[C@@H]1[C@@H](OC(=O)C2=CC=CC=C2)[C@@H](OC(=O)C2=CC=CC=C2)[C@H](OC(C)=O)O1 |&1:10,11,21,31,r|
- CAS ??????
- 6974-32-9(CAS DataBase Reference)
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- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xi | ||
|---|---|---|---|
| ?? ???? ?? | 36/38 | ||
| ????? | 22-24/25-37/39-26 | ||
| WGK ?? | 3 | ||
| TSCA | Yes | ||
| HS ?? | 29400090 |
beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate C??? ??, ??, ??
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β-D-Ribofuranose 1-Acetate 2,3,5-Tribenzoate is an optically active ribose derivative. It is white to orange to green powder to crystals, slightly soluble in methanol, and can be used as a starting material for nucleoside synthesis. The substance is also used as an intermediate for Clofarabine, which belongs to a class of drugs called purine nucleoside antimetabolites and is used to treat acute lymphoblastic leukemia (ALL) in children and young adults aged 1 to 21 years.??? ??
white to light yellow crystal powde??
An inhibitor of neutrophil-keyhole limpet hemocyanin adhesion?? ??
Beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate, also known as 1-O-Acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose, is a ribose-derived compound used in nucleoside synthesis.??
The commonly used 1-O-acetyl-2,3,5- tri-O-benzoyl-β-D-ribofuranose (beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate) can be employed in the glycosylation of 7-deazapurines when 7-halogenated nucleobases are used. Using common ribosugars such as 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose resulted in the formation of orthoamides when the pyrrole ring was not functionalized. The glycosylation yield and glycosylation position of 7-deazapurines with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose depends strongly on 7-substituents (H vs halogen) and amino protecting groups. It could be used to synthesize 5-Bromo-4-chloro-2-[(N2-isobutyryl){2,3,5-tri-O-benzoyl-β-Dribofuranosyl}]amino-7H-pyrrolo[2,3-d]pyrimidine.Purification Methods
Recrystallise it from EtOH or isoPrOH. [Helv Chim Acta 42 1171 1959, NMR: J Org Chem 33 1799 1968, IR: Chem Pharm Bull Jpn 11 188 1963, Beilstein 17/6 V 213.]beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate ?? ?? ? ???
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beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate ?? ??
???( 524)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
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beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate ?? ??:
1,2,3,5-TETRA-O-ACETYL-BETA-L-RIBOFURANOSE
1-O-Acetyl-3,5-bis-(4-chlorobenzoyl)-2-deoxy-D-ribose
ALPHA-L-ERYTHRO-PENTOFURANOSYL CHLORIDE-2-DEOXY-BIS(4-METHYL BENZOATE)
1,3,5-Tri-O-benzoyl-D-ribofuranose
2,3-O-Isopropylidene-D-ribonic gamma-lactone
1,3,5-TRI-O-BENZOYL-ALPHA-L-RIBOFURANOSE
2,3-O-Isopropylidene-D-ribofuranoside
1-Chloro-3,5-di-(4-chlorobenzoyl)-2-deoxy-D-ribose
1-O-Methyl-2-deoxy-D-ribose
(5-acetyloxy-3,4-dibenzoyloxy-oxolan-2-yl)methyl benzoate
1-ACETYL-2,3,5-TRI-O-BENZOYL-BETA-L-RIBOFURANOSE,1-O-ACETYL-2,3,5-TRI-O-BENZOYL-BETA-L-RIBOFURANOSE
1-O-ACETYL-2,3,5-TRI-O-BENZOYL-D-RIBOFURANOSE
beta-D-Ribofuranose 1-acetate 2,3,5-tribenzoate
1-O-Acetyl-2,3,5-tri-O-(4-chlorobenzoyl)-beta-D-ribofuranose
1,2,3,5-Tetra-O-benzoyl-2C-methyl-D-ribofuranose
1-O-ACETYL 2,3,5-TRI-O-BENZOYL-BETA-D-[1-13C]RIBOFURANOSIDE
1-O-ACETYL 2,3,5-TRI-O-BENZOYL-BETA-D-[UL-13C5]RIBOFURANOSIDE
1-O-ACETYL 2,3,5-TRI-O-BENZOYL-BETA-D-[5-13C]RIBOFURANOSIDE