PD0166285
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PD0166285 ??? ???
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- ?? ??:
- 185039-89-8
- ???:
- PD0166285
- ???(??):
- PD0166285;PD 0166285;PD-0166285;PD-0166285,Wee1,Inhibitor,inhibit,PD 0166285,Apoptosis,PD0166285;6-(2,6-Dichloro-phenyl)-2-[4-(2-diethylaMino-ethoxy)-phenylaMino]-8-Methyl-8H-pyrido[2,3-d]pyriMidin-7-one;Pyrido[2,3-d]pyriMidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[[4-[2-(diethylaMino)ethoxy]phenyl]aMino]-8-Methyl-
- CBNumber:
- CB32664142
- ???:
- C26H27Cl2N5O2
- ??? ??:
- 512.43
- MOL ??:
- 185039-89-8.mol
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PD0166285 ??
- ?? ?
- 665.3±65.0 °C(Predicted)
- ??
- 1.315±0.06 g/cm3(Predicted)
- ?? ??
- under inert gas (nitrogen or Argon) at 2–8 °C
- ???
- DMSO:60.0(Max Conc. mg/mL);117.1(Max Conc. mM)
- ?? ?? (pKa)
- 9.65±0.25(Predicted)
- ??? ??
- Solid
- ??
- Light yellow to yellow
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ????(GHS): |
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| ?? ?: |
Warning |
| ??·?? ??: |
| ?? |
??·?? ?? |
?? ?? |
?? |
?? ? |
?? ?? |
P- ?? |
| H302 |
??? ??? |
?? ?? ?? - ?? |
?? 4 |
?? |
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P264, P270, P301+P312, P330, P501 |
| H315 |
??? ??? ??? |
????? ?? ????? |
?? 2 |
?? |
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P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
?? ?? ??? ??? |
?? ? ?? ?? ??? ?? |
?? 2A |
?? |
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P264, P280, P305+P351+P338,P337+P313P |
| H335 |
?? ???? ??? ? ?? |
?? ???? ?? - 1? ??;???? ?? |
?? 3 |
?? |
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| ??????: |
| P261 |
??·?·??·???·??·...·????? ??? ????. |
| P305+P351+P338 |
?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????. |
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PD0166285 C??? ??, ??, ??
??
PD 0166285 is a pyridopyrimidine compound that inhibits Wee1, which is a Ser/Thr kinase that regulates the cell cycle (1,2).
PD0166285 ?? ?? ? ???
???
?? ??
PD0166285 ?? ??
???( 51)?? ??
