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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone ??? ???
?? ??:
32384-65-9
???:
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
???(??):
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, δ-lactone;Dagliptin Impurity;oxy)-6-((triMethyL;Cagliflozin Impurity 9;Englitazinintermediate;Dapagliflozin Impurity 12;Canagliflozin Related Impurity 9;(3R,4S,5R,6R)-3,4,5-tris(triMethyL;Canagliflozin Impurity 9(Dagelin impurity 11)
CBNumber:
CB32610563
???:
C18H42O6Si4
??? ??:
466.87
MOL ??:
32384-65-9.mol

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone ??

?? ?
417℃
??
0.97
???
171℃
?? ??
under inert gas (nitrogen or Argon) at 2-8°C
???
?????(???? ??), ???????(?? ???), ???(?? ???)
??? ??
??
??
??~???
???
??? ???
InChI
InChI=1/C18H42O6Si4/c1-25(2,3)20-13-14-15(22-26(4,5)6)16(23-27(7,8)9)17(18(19)21-14)24-28(10,11)12/h14-17H,13H2,1-12H3/t14-,15-,16+,17-/s3
InChIKey
VNGTZLYNGGLPIZ-NELUYGJANA-N
SMILES
O([C@@H]1[C@H](C(=O)O[C@H](CO[Si](C)(C)C)[C@H]1O[Si](C)(C)C)O[Si](C)(C)C)[Si](C)(C)C |&1:1,2,6,13,r|
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 2931900090
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone C??? ??, ??, ??

??? ??

Pale yellow oil

??

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.

2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone ?? ?? ? ???

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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone ?? ??

???( 466)?? ??
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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone ?? ??:

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