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Propacetamol

Propacetamol ??? ???
?? ??:
66532-85-2
???:
Propacetamol
???(??):
Propacetamo;Pro-Dafalgan;PROPACETAMOL;Propacatemol;Propacetamol USP/EP/BP;4-Acetamidophenyl N,N-diethylglycinate;4-acetamidophenyl N,N-diethylaminoacetate;N,N-Diethylglycine 4-(acetylamino)phenyl ester;(Diethylamino)acetic acid 4-(acetylamino)phenyl;Glycine, N,N-diethyl-, 4-(acetylamino)phenyl ester
CBNumber:
CB2759429
???:
C14H20N2O3
??? ??:
264.32
MOL ??:
66532-85-2.mol

Propacetamol ??

???
55-57 °C
?? ?
434.5±30.0 °C(Predicted)
??
1.132±0.06 g/cm3(Predicted)
?? ??
Store at -20°C
???
H2O : 100 mg/mL (378.33 mM; Need ultrasonic)
?? ?? (pKa)
14.20±0.70(Predicted)
??? ??
Solid
??
White to off-white
CAS ??????
66532-85-2(CAS DataBase Reference)

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Propacetamol C??? ??, ??, ??

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Propacetamol is the prodrug of paracetamol (acetaminophen), used for intravenous administration. It results from eombination of paracetamol and diethylglycine. Causes contact dermatitis and airborne dermatitis in nurses. Allergenic properties are due to the N,N' -diethylglycine moiety, and not to the paracetamol moiety.

??

Propacetamol hydrochloride is a water-soluble prodrug for intravenous administration resulting in the liberation of paracetamol.

?? ?? ??

Propacetamol is a prodrug of paracetamol (acetaminophen) used for intravenous administration. It results from the combination of paracetamol and diethylglycine. It caused contact (hand and airborne) dermatitis in nurses and acute systemic dermatitis (pompholyx and nummular dermatitis, generalized eczema, urticaria-like eruption) in nurses who had became sick and received intravenous propacetamol. Allergenic properties are due to the N,N-diethylglycine moiety, and not to the paracetamol moiety. Propacetamol is now substituted by a solution of paracetamol in mannitol (Perfalgan?).

Propacetamol ?? ?? ? ???

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Propacetamol ?? ??

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