???? ????
|
|
???? ???? ??
- ???
- ≥300 °C(lit.)
- ?? ?
- 234 °C (17 mmHg)
- ??
- 1.043 g/mL at 20 °C (lit.)
- Pour Point
- -62
- ???
- n
20/D 1.445
- ???
- 300 °C
- ?? ??
- Store below +30°C.
- ???
- Miscible with acetone, ethanol, and vegetable oil; practically insoluble in water.
- ?? ?? (pKa)
- 11.30±0.29(Predicted)
- ??? ??
- ??
- ??
- ???
- ??
- ?? ??
- ???
- ???
- Merck
- 14,1564
- BRN
- 1806072
- InChIKey
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N
- LogP
- 4.324 (est)
- CAS ??????
- 77-94-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 25 | ||
| ????? | 26-36/37/39-45-24/25 | ||
| ????(UN No.) | UN 2811 6.1/PG 2 | ||
| WGK ?? | 3 | ||
| RTECS ?? | TZ8608000 | ||
| TSCA | Yes | ||
| HS ?? | 29181500 | ||
| ???? ?? | KE-34032 |
???? ???? C??? ??, ??, ??
??? ??
Tributyl citrate is a clear, odorless, practically colorless, oily liquid.??
Tributyl Citrate, is a non-phthalate plasticizer, that can be used for the preparation of resins. It can also used for the synthesis of Acetyl Tributyl Cirate, a valuable biodegradable plasticizer of low toxicity, found in nail polish and other cosmetics.?? ??
Tributyl citrate is prepared by the esterification of citric acid with butanol.?? ??
Tributyl citrate is an ester of citric acid. It is used to plasticize polymers for coating solid drug dosage forms, tablets and capsules.Certified pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to pharmacopeia primary standards.
Pharmaceutical Applications
Tributyl citrate is used to plasticize polymers in formulated pharmaceutical coatings. The coating applications include capsules, tablets, beads, and granules for taste masking, immediate release, sustained-release, and enteric formulations.Safety
Tributyl citrate is used in oral pharmaceutical formulations. It is generally regarded as an essentially nontoxic and nonirritating material. However, ingestion of large quantities may be harmful.LD50 (cat, oral): >50 mL/kg
LD50 (mouse, IP): 2.9 g/kg
LD50 (rat, oral): >30 mL/kg
??
Tributyl citrate should be stored in well-closed containers in a cool, dry location at temperatures not exceeding 38℃. When stored in accordance with these conditions, tributyl citrate is a stable material.? ???
Tributyl citrate is incompatible with strong alkalis and oxidizing materials.Regulatory Status
Approved in the USA for indirect food contact in food films. Included in the Canadian List of Acceptable Non-medicinal Ingredients.???? ???? ?? ?? ? ???
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???( 490)?? ??
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