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???????????,FR2054

???????????,FR2054
???????????,FR2054 ??? ???
?? ??:
37134-40-0
???:
???????????,FR2054
???(??):
???????????,FR2054
???:
BicozaMycin benzoate, FR 2054
???(??):
FR2054;BicycloMycin benzoate;Bicyclomycin benzoate,FR 2054;BicozaMycin benzoate, FR 2054;Bicyclomycin, 3'-benzoate (9CI);(2S,3S)-2,3-dihydroxy-3-((1S,6R)-6-hydroxy-5-methylene-8,10-dioxo-2-oxa-7,9-diazabicyclo[4.2.2]decan-1-yl)-2-methylpropyl benzoate
CBNumber:
CB22703705
???:
C19H22N2O8
??? ??:
406.39
MOL ??:
37134-40-0.mol
MSDS ??:
SDS

???????????,FR2054 ??

???
>123°C (dec.)
?? ?
788.6±60.0 °C(Predicted)
??
1.49±0.1 g/cm3(Predicted)
?? ??
Hygroscopic, -20°C Freezer, Under inert atmosphere
???
DMSO(?? ???), ???(?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
9.82±0.60(Predicted)
??
???

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???????????,FR2054 C??? ??, ??, ??

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BicozaMycin benzoate, FR 2054 is a polar metabolite first isolated from Streptomyces sapporonensis in 1972, with activity against Gram negative bacteria. The selective Gram negative profile of bicyclomycin is rare among Streptomyces metabolites, and in an effort to overcome its poor in vivo absorption, the benzoate ester was prepared by reaction with the more exposed primary alcohol. BicozaMycin benzoate, FR 2054 benzoate has limited use as a veterinary antibiotic.

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???????????,FR2054 ?? ??:

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