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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride ??? ???
?? ??:
30827-99-7
???:
4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride
???(??):
AEBSF;AEBSF HCL;AEBSF HYDROCHLORIDE;CS-2583;AEBSF HCI;PEFABLOC SC;PEFABLOC(R) SC;AEBSF Solution;PEFABLOC SC PLUS;TIMTEC-BB SBB003219
CBNumber:
CB1769137
???:
C8H11ClFNO2S
??? ??:
239.69
MOL ??:
30827-99-7.mol
MSDS ??:
SDS

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride ??

???
175-177 °C
?? ??
2-8°C
???
H2O: ???50mg/mL(pH 7 ???? ?? ?? ? ?? 6?? ?? ?????. pH 7?? ? ???? ?? ??? pH ??? ?? ???.)
??? ??
??
??
???
??????(pH)
pH3.0~5.0 (10g/L, 25℃)
???
10g/L(20℃)
??
Moisture Sensitive
BRN
7604627
???
??? ?? ?????? 1? ?? ??????. pH <7? ??? ???? ??? ?? ?? 6?? ?? ??????.
InChIKey
WRDABNWSWOHGMS-UHFFFAOYSA-N
CAS ??????
30827-99-7(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? C,Xi
?? ???? ?? 34-36/37/38
????? 45-36/37/39-26-36
????(UN No.) UN 3261
WGK ?? 3
?? ?? ?? Corrosive
?? ?? 8
???? II
HS ?? 29214990
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
NFPA 704
1
3 0

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride C??? ??, ??, ??

??

AEBSF is a water soluble, irreversible, broad spectrum inhibitor of serine proteases, including trypsin, chymotrypsin, plasmin, thrombin, and kallikreins. AEBSF can also prevent the activation of the ROS generator, NADPH oxidase. At 10-50 μg, AEBSF can attenuate airway inflammation in a mouse model of airway allergy. AEBSF maintains stability in slightly acidic aqueous solutions and serves as a nontoxic alternative to the organophosphate inhibitors, PMSF and DFP.

??? ??

white powder

??

AEBSF is extensively used in studies aiming to describe cholesterol regulatory genes due to its potent ability to inhibit Site-1-protease (S1P). This serine protease, located in the Golgi apparatus, is responsible for activating the sterol regulatory element-binding proteins. By selectively inhibiting S1P, AEBSF can be used to characterize the downstream result of SREBP inhibition and its influence on cholesterol regulation.

?? ??

Pefabloc? SC is a trypsin inhibitor, which can be used in the synthesis of its arginine-like analogue, 4-(2-guanidinoethyl)benzenesulfonyl fluoride.

4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride ?? ?? ? ???

???

?? ??


4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride ?? ??

???( 395)?? ??
??? ?? ??? ?? ?? ? ??
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4-(2-Aminoethyl)benzenesulfonylfluoride hydrochloride ?? ??:

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