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06:0 Lyso PA (LPA) has been used in the structure-activity relationship (SAR) analysis with G-protein receptor GPR92. It has also been used in lipid assay in the treatment of serum-starved primary mouse embryonic fibroblast cells.

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Lysophosphatidic acid (LPA) is the major component of serum.?It has a free hydroxyl and phosphate moiety. LPA is hydrophilic and is not associated with the?membrane.

Biochem/physiol Actions

Lysophosphatidic acid (LPA) acts as the precursor for the synthesis of phospholipids in eukaryotes and prokaryotes. It prevents differentiation of neuroblastoma and myoblast, supports in neurotransmitter release and smooth muscle contraction. LPA plays a vital role in tissue healing and wound regeneration. It binds to G-protein coupled receptors. LPA has mitogenic?properties. It functions as an intercellular?signaling?molecule. LPA is involved in the initiation of neuropathic pain.

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