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D-????-????

D-????-????
D-????-???? ??? ???
?? ??:
123-78-4
???:
D-????-????
???(??):
D-????-????
???:
D-ERYTHRO-SPHINGOSINE
???(??):
SPHINGOSINE;D-SPHINGOSINE;Sphingosine (d18:1);CEREBROSIDE;Sphingenine;SPHINGOSINE, D-ERYTHRO;(2S,3R,E)-2-aMinooctadec-4-ene-1,3-diol;BRAIN, BOVINE;4-SPHINGENINE;D-Sphingenine
CBNumber:
CB1262764
???:
C18H37NO2
??? ??:
299.49
MOL ??:
123-78-4.mol
MSDS ??:
SDS

D-????-???? ??

???
74.2-78.1 °C
?? ?
440.8°C (rough estimate)
??
0.9758 (rough estimate)
???
1.5000 (estimate)
?? ??
-20°C
???
?????: 20mg/mL, ???? ???? ?? ??? ???
?? ?? (pKa)
11.80±0.45(Predicted)
??? ??
?? ?? ?? ?? ??
??
???? ?????
Merck
14,8747
BRN
1727294
???
????. ??, ???, ????? ???? ????.
InChIKey
WWUZIQQURGPMPG-KRWOKUGFSA-N
CAS ??????
123-78-4
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????? 22-24/25
WGK ?? 3
F ?????? 1-8-10
HS ?? 29221985
???? ?? KE-01518
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
NFPA 704
0
2 0

D-????-???? C??? ??, ??, ??

??? ??

White Crystalline Solid

??

D-erythro-Sphingosine is used to inhibits protein kinase C and calmodulin-dependent enzymes, induces apoptosis. And also used to constituent of cell membranes.

??

cerebroside: Any one of a class ofglycolipids in which a single sugarunit is bound to a sphingolipid. The most commoncerebrosides are galactocerebrosides,containing the sugar group galactose;they are found in the plasma membranesof neural tissue and are abundantin the myelin sheaths ofneurones.

?? ??

Sphingosine (d18:1) is a spingoid base present in plant and animals. It has 2-amino-1,3-diol functionality and its extraction from animal tissue is laborious. Sphingosine (d18:1) synthesis is performed by chirospecific method using D-galactose.

???? ??

Inhibitor of protein kinase C and calmodulin-dependent enzymes, but may stimulate mast cells by activation of protein kinase C.

Purification Methods

D-Sphingosine is purified by recrystallisation from EtOAc, Et2O or pet ether (60-80o). It is insoluble in H2O but is soluble in Me2CO, EtOH and MeOH. It has IR bands at 1590 and 875 cm-1, and is characterised as the tribenzoate m 122-123o (from 95% EtOH). [Tipton Biochemical Preparations 9 127 1962.]

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