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????????????? ??? ???
?? ??:
3476-50-4
???:
?????????????
???(??):
?????????????
???:
trimethylcolchicinic acid methyl ether
???(??):
NSC 201400;Deacetylcolchicine;Desacetylcolchicine;Colchicine Impurity 22;(-)-7-Deacetylcolchicine;(S)-N-Deacetyl Colchicine;(-)-N-Deacetyl Colchicine;Colchicine N-Desacetyl (S)-Isomer;trimethylcolchicinic acid methyl ether;7-AMino-6,7-dihydro-1,2,3,10-tetraMethoxy-benzo[a]heptalen-9(5H)-one
CBNumber:
CB11317339
???:
C20H23NO5
??? ??:
357.4
MOL ??:
3476-50-4.mol

????????????? ??

?? ?
490.03°C (rough estimate)
??
1.2532 (rough estimate)
???
1.5614 (estimate)
?? ??
-20°C Freezer, Under Inert Atmosphere
???
DMSO: 25mg/mL; Ethanol: 25mg/mL
??? ??
??? ??
?? ?? (pKa)
8.62±0.40(Predicted)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H300 ??? ???? ?? ?? ?? - ?? ?? 1,2 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P280, P305+P351+P338, P310
H340 ???? ??? ??? ? ?? (????? ???? ????? ???? ???? ???? ??? ?? ????? ??? ???? ??) ???? ???? ?? ?? 1A, 1B ?? GHS hazard pictograms
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P310 ???? ?? ????(??)? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
4 0

????????????? C??? ??, ??, ??

??? ??

Yellow Solid

??

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.

????????????? ?? ?? ? ???

???

?? ??

N-[(S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]-2,2,2-trifluoroacetamide

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???( 31)?? ??
??? ?? ??? ?? ?? ? ??
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