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101975-10-4
???:
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???(??):
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???:
ZARDAVERINE
???(??):
ZARDAVENINE;ZARDAVERINE;6-(4-(Difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one;6-[4-(DIFLUOROMETHOXY)-3-METHOXYPHENYL]-3(2H)-PYRIDAZINONE;3-[4-(difluoromethoxy)-3-methoxyphenyl]-1H-pyridazin-6-one;3-[4-(difluoromethoxy)-3-methoxy-phenyl]-1H-pyridazin-6-one;3(2H)-Pyridazinone, 6-[4-(difluoromethoxy)-3-methoxyphenyl]-
CBNumber:
CB1106730
???:
C12H10F2N2O3
??? ??:
268.22
MOL ??:
101975-10-4.mol
MSDS ??:
SDS

????? ??

??
1.38±0.1 g/cm3(Predicted)
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Store at RT
???
DMSO : 100 mg/mL (372.83 mM; Need ultrasonic)
??? ??
??? ?? ?? ??.
?? ?? (pKa)
10.89±0.40(Predicted)
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White to light yellow
CAS ??????
101975-10-4

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WGK ?? 3

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Zardaverine can selectively inhibit?phosphodiesterase III (PDE III) from human platelets and?phosphodiesterase IV (PDE IV) from human polymorphonuclear leucocytes (PMN).

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ChEBI: A pyridazinone derivative in which pyridazin-3(2H)-one is substituted at C-6 with a 4-(difluoromethoxy)-3-methoxyphenyl group. It is a phosphodiesterase inhibitor, selective for PDE3 and 4.

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Phosphodiesterase inhibitor, selective for PDE3 and 4 (IC 50 values are 0.5 and 0.8 μ M respectively). Also available as part of the Phosphodiesterase Inhibitor Tocriset™ .

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?????? ?????, ????? Glyoxylic acid monohydrate AMMONIUM

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