ChemicalBook >?? ???? >?? ??>?? ??>???>(R)-(-)-2-?????

(R)-(-)-2-?????

(R)-(-)-2-????? ??? ???

?? ??:: 938-79-4

???:: (R)-(-)-2-?????

???(??):: (R)-(-)-2-?????

???:: (R)-(-)-2-PHENYLBUTYRIC ACID

???(??):: (R)-2-Phenylbutanoic acid;(2R)-2-Phenylbutyric acid;Phenobarbital Impurity 23;(2R)-2-Phenylbutanoic acid;(R)-(-)-2-PHENYLBUTYRIC ACID;(αR)-α-Ethylbenzeneacetic acid;(R)-(-)-2-Phenylbutyric acid,99%;(R)-(-)-2-Phenylbutyric acid 99%;(r)-(-)-à-ethylphenylacetic acid;(R)-(-)-2-Phenylbutyricacid,98+%

CBNumber:: CB0683524

???:: C10H12O2

??? ??:: 164.2

MOL ??:: 938-79-4.mol

?? ?? 88

(R)-(-)-2-????? ??

??: [α]D20 -92～-98゜ (c=4, C6H5CH3)

?? ?: 102-104 °C/0.4 mmHg (lit.)

??: 1.055 g/mL at 25 °C (lit.)

???: n20/D 1.516

???: >230 °F

?? ??: Refrigerator

???: ?????(?? ???), ???(?? ???), ???(?? ???)

??? ??: ??

??: ???

optical activity: [α]20/D 93°, c = 0.9 in toluene

BRN: 2327346

CAS ??????: 938-79-4(CAS DataBase Reference)

?? ? ?? ??
?? ? ???? ?? (GHS)

??? ??	Xn
?? ???? ??	22
?????	23-36
WGK ??	3
HS ??	29163900

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P

??????:

P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P321	(…) ??? ???.
P332+P313	?? ??? ??? ???? ??· ??? ????.

NFPA 704

	0
2		0

(R)-(-)-2-????? C??? ??, ??, ??

??? ??

clear colorless liquid

??

(R)-(-)-2-Phenylbutyric Acid, is the metabolite of Butamirate (B690025), which is a novel antitussive drug.

Purification Methods

Purify the acids by distillation at atmospheric pressure using an efficient column. The acid chlorides have b 106-107o/20mm, []D () and (+) 108o (c 2, *C6H6). [Levene et al. J Biol Chem 100 589 1933, Gold & Aubert Helv Chim Acta 41 1512 1958, ORD in heptane: Rothen & Levene J Chem Phys 7 975 1939, Beilstein 9 III 2461.]

(R)-(-)-2-????? ?? ?? ? ???

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(E)-2-??-2-??? 2-????????? ????????? 2-??????

?? ??

(S)-(+)-2-PHENYLBUTYRIC ACID

(R)-(-)-2-????? ?? ??

???( 88)?? ??

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(R)-(-)-2-????? ?? ??:

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