???????
|
|
??????? ??
- ???
- 215-220 °C
- ?? ?
- 194.21°C (rough estimate)
- ??
- 0.801 g/mL at 20 °C
- ?? ??
- 560kg/m3
- ???
- 0.001Pa at 25℃
- ???
- n
20/D 1.365
- ???
- 14 °C
- ?? ??
- Store below +30°C.
- ???
- ??? ???, ??? ? ???? ?????.
- ??? ??
- ??? ??
- ?? ?? (pKa)
- pK1:8.45(0);pK2:8.88(-1) (25°C)
- ??
- ??~?? ???
- ???
- 11.17g/L(??)
- ??
- Light Sensitive & Hygroscopic
- Merck
- 14,7328
- BRN
- 1341907
- InChIKey
- QCDYQQDYXPDABM-UHFFFAOYSA-N
- LogP
- 0.55 at 25℃
- CAS ??????
- 108-73-6(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | F,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 11-36/37/38-34-43 | ||
| ????? | 7-16-24/25-45-36/37/39-26-36/37-37/39 | ||
| ????(UN No.) | UN 1170 3/PG 2 | ||
| WGK ?? | 2 | ||
| RTECS ?? | SY1050000 | ||
| TSCA | Yes | ||
| HS ?? | 29072900 | ||
| ?? | LD50 in mice, rats (g/kg): 4.7, 4.0 i.g. (Cahen) | ||
| ???? ?? | KE-02671 |
??????? C??? ??, ??, ??
??
Phloroglucinol is a naturally occurring phenol that exhibits diverse biological activities. Phloroglucinol protects V79-4 Chinese hamster lung fibroblast cells from oxidative stress and inhibits lipid peroxidation by scavenging reactive oxygen species (ROS). It induces apoptosis in HT-29 human colon cancer cells and inhibits metastasis of BT549 and MDA-MB-231 human breast cancer cells. Phloroglucinol protects primary neurons from β-amyloid-induced dendritic spine loss in vitro and shortens the latency to find the platform in a Morris water maze test in an Alzheimer’s disease (AD) mouse model. Phloroglucinol has been used to stain histological plant sections and in the synthesis of numerous natural products. Phloroglucinol slows the frequency and decreases the amplitude of contraction in isolated rabbit and rat intestine at a concentration of 100 and 1 μM, respectively. Formulations containing phloroglucinol have been used as antispasmodics.??? ??
white to light yellow crystal??? ??
Phloroglucinol crystallizes in the anhydrous form or as the dihydrate. Recrystallization from water gives the dihydrate, which is colorless, oderless, sweet in taste, and forms rhombic crystals. The dihydrate is converted into the anhydrous form by heating at 110 ℃. Phloroglucinol sublimes at higher temperatures with partial decomposition.??
Phloroglucinol is mainly used as a coupling agent in printing. It is an active component of Tollen's reagent and Gunzburg reagent used to test pentoses and hydrochloric acid in gastric juice respectively. In analytical chemistry, it is used to study condensed tannins by means of depolymerization. It is also involved in the synthesis of 2,4,6-triamino-1,3,5- trinitrobenzene, trinitrophloroglucinol and pharmaceuticals like flopropione.??
ChEBI: Phloroglucinol is a benzenetriol with hydroxy groups at position 1, 3 and 5. It has a role as an algal metabolite.?? ??
Phloroglucinol (phlo) is a phenol derivative that shows cyctoprotective effect from oxidative damage by enhancing the activity of cellular catalase.It can react with benzaldehyde derivatives to form phloroglucinol-based microporous polymeric organic frameworks (phlo-POF) with potential applications in ion-exchange and gas adsorption.
Phlo can also be used to prepare synthetic analogs of A-type proanthocyanidins (PACs) such as 2,8-dioxabicyclo[3.3.1]nonane derivatives by reacting with the corresponding flavylium salts.
?? ??
Phloroglucinol is a trihydroxybenzene with antithrombotic, profibrinolytic, antimicrobial, antimalarial, cancer chemopreventive, anti-HIV and anti-leishmanial activities. Phloroglucinol (PG) is a biosynthetic precursor of the 2,4-diacetylphloroglucinol (DAPG) an antibiotic against soil-borne diseases. Phloroglucinol is a useful intermediate because it is polyfunctional.Safety Profile
Moderately toxic by subcutaneous and intraperitoneal routes. Mildly toxic by ingestion. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes. Used in diazo-type printing and textile dyeing, in microscopy as a bone specimen decalcifierPurification Methods
Crystallise the triol from water, and store it in the dark under nitrogen. [Beilstein 6 IV 7361.]??????? ?? ?? ? ???
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