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PD 145305

PD 145305 ??? ???
?? ??:
90536-15-5
???:
PD 145305
???(??):
PD 145305;3-phenyl-2-sulfanylpropanoic acid;Benzenepropanoic acid, α-mercapto-;S(+)-2-mercapto-3-phenylpropionic acid
CBNumber:
CB0334574
???:
C9H10O2S
??? ??:
182.24
MOL ??:
90536-15-5.mol

PD 145305 ??

???
46 °C
?? ?
184-187 °C(Press: 11-12 Torr)
??
1.232±0.06 g/cm3(Predicted)
?? ??
Store at -20°C
???
≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
?? ?? (pKa)
3.60±0.10(Predicted)
??? ??
solution in ethanol.
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H314 ??? ?? ??? ?? ??? ??? ????? ?? ????? ?? 1A, B, C ?? GHS hazard pictograms P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P260 ??·?·??·???·??·...·????? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P301+P330+P331 ???? ?? ?????. ??? ?? ?? ???.
P302+P352 ??? ??? ??? ?? ????.
P303+P361+P353 ??(?? ????)? ??? ??? ?? ??? ??? ????? ??? ?? ????/?????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P310 ?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P362 ??? ??? ?? ?? ?? ?????
P363 ?? ??? ??? ??? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
3
1 0

PD 145305 C??? ??, ??, ??

??

PD 145305 is an inactive analog of PD 150606 , a selective inhibitor of calpains (Kis = 0.21 and 0.37 μM for μ- and m-calpain, respectively). It is inactive at concentrations up to 500 μM.

PD 145305 ?? ?? ? ???

???

?? ??

PD 145305 ?? ??

???( 30)?? ??
??? ?? ??? ?? ?? ? ??
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