PERUVOSIDE
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PERUVOSIDE ??
- ???
- 161-164°C
- ??
- D22 -71.7° (c = 1.54 in methanol)
- ?? ?
- 540.83°C (rough estimate)
- ??
- 1.1277 (rough estimate)
- ???
- 1.5500 (estimate)
- ?? ??
- 2-8°C
- ???
- ?????(?? ???), DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 12.92±0.70(Predicted)
- ??? ??
- ??
- ??
- ???
??
| ??? ?? | T | ||
|---|---|---|---|
| ?? ???? ?? | 23/24/25 | ||
| ????? | 36/37/39-45 | ||
| WGK ?? | 3 | ||
| RTECS ?? | FH4915000 | ||
| ?? | cat,LD50,intravenous,145ug/kg (0.145mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGCARDIAC: ARRHYTHMIAS (INCLUDING CHANGES IN CONDUCTION)CARDIAC: CHANGE IN RATE,Archives Internationales de Pharmacodynamie et de Therapie. Vol. 126, Pg. 412, 1960. |
PERUVOSIDE C??? ??, ??, ??
??
Peruvoside is a cardiac glycoside with the same inotropic and chronotropic effects on heart function as Ouabain (O714500).?? ???
This cardiotonic glycoside or cardenoide (FW = 548.67 g/mol; CAS 1182- 87-2), named systematically as (3b,5b)-3-(6-deoxy-3-O-methyl-a-Lglucopyranosyl)oxyl-14-hydroxy-19-oxocard-20(22)-enolide, a component of neriperside from Thevetia neriifolia (yellow oleander) resembles oubain in its inotropic (force of contraction) and chronotropic (rate of contraction) effects on heart function. Orally administered peruvoside is effective in treating congestive heart failure. Note the structural similarities of the aglycon to digitoxigenin. Target(s): Na+ /K+ -exchanging ATPase.PERUVOSIDE ?? ?? ? ???
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?? ??
PERUVOSIDE ?? ??
???( 57)?? ??
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|---|---|---|---|---|---|
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