???????????
|
|
??????????? ??
- ???
- -24 °C
- ?? ?
- 42-43 °C/10 mmHg (lit.)
- ??
- 1.187 g/mL at 25 °C (lit.)
- ???
- n
20/D 1.466(lit.)
- ???
- 86 °F
- ?? ??
- Store below +30°C.
- ???
- 40g/L
- ??? ??
- ??
- ?? ?? (pKa)
- 8.04±0.10(Predicted)
- ??
- ???
- ???
- 40g/L(20℃)
- ??
- Air Sensitive
- BRN
- 506259
- InChIKey
- MKIJJIMOAABWGF-UHFFFAOYSA-N
- CAS ??????
- 2365-48-2(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn,T | ||
|---|---|---|---|
| ?? ???? ?? | 10-20/22-36/37/38-25 | ||
| ????? | 26-36/37-45-36/37/39-28A | ||
| ????(UN No.) | UN 1992 3/PG 3 | ||
| WGK ?? | 1 | ||
| RTECS ?? | AI7350000 | ||
| TSCA | Yes | ||
| ?? ?? | 3 | ||
| ???? | III | ||
| HS ?? | 29309070 | ||
| ?? ?? ??? | 2365-48-2(Hazardous Substances Data) | ||
| ?? | mouse,LD50,intraperitoneal,100mg/kg (100mg/kg),National Technical Information Service. Vol. AD277-689, |
??????????? C??? ??, ??, ??
??? ??
CLEAR COLOURLESS LIQUID??
Methyl Thioglycolate is an derivative of Thioglycolic Acid (T350760), an organic compound containing both a thiol and a carboxylic acid functional groups. Thioglycolic Acid and its derivatives are oft en used in organic synthesis as a nucleophile in thioglycolysis reactions and is also used as a S transfer agent for sulfonyl chloride synthesis. Methyl Thioglycolate have been studied for the its inf luence on neocarzinostatin activation and expression of DNA damage.?? ??
Adding thioglycollic acid with purity of between 70.0 and 96.0 percent and methanol with purity of between 95.0 and 99.9 percent into a reaction device according to the molar ratio of 1:1.3-4.0; subsequently, adding an activating agent into the reaction device, stirring and heating for reaction; and after the reaction is finished, carrying out separatory distillation on reaction products to obtain the methyl thioglycolate. The activating agent is a p-toluenesulfonic acid methanol solution with a mass concentration of between 20 and 30 percent, and the use amount is 0.5 to 1.0 percent of the total mass of relative input materials.?? ??
Methyl thioglycolate is a chemical compound that is used in the pharmaceutical industry as an intermediate. It has been used to synthesize anti-inflammatory drugs, such as aspirin and ibuprofen, and also for the treatment of autoimmune diseases. Methyl thioglycolate binds to amino acids on the surface of bacteria, which prevents them from functioning properly. This binding causes the cells to stop growing and die.?? ??
Methyl thioglycolate reacts with nonprotein component of the antitumor antibiotic neocarzinostatin to form 1:1 adduct. It reacts with isothiocyanate to form Rhodanine.??????????? ?? ?? ? ???
???
?? ??
Methyl 3-amino-4-methylthiophene-2-carboxylate
??3-???-4-?????-2-???????
METHYL 3-AMINO-6-METHYLTHIOPHENO[2,3-B]PYRIDINE-2-CARBOXYLATE
5-???-4-??????-3-?????
3-AMINO-6-METHYLTHIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE
??3-???-4-?????-2-???????
5-???-4-??????-3-???????
Methyl 4-oxotetrahydrothiophene-3-carboxylate
5-???-4-??????-3-????
3-???-4,5,6,7-???????-??[B]???-2-??????????
???-3-????
3-AMINOTHIOPHENE-2-CARBOXAMIDE
???4-??????-2,3-???????????
Methyl 3-amino-2-thiophenecarboxylate
3-???-4-??-2-????????
??3-??????-2-??????
Methyl 3-hydroxythiophene-2-carboxylate
S-Methyl isovalerate
4-??-3-???-2-(???????)-4,5-???????
1-Benzothiophen-5-amine
??3-???-5-(tert-??)???-2-???????
?????-??
5-???-4-??????-3-????????
4-??????-3-??????
4-??????-3-?????
4-Chlorothieno[3,2-d]pyrimidine
3-???-5-(TERT-??)???-2-???????
METHYL 4-METHOXYTHIOPHENE-3-CARBOXYLATE
5-???-1-?????-2-?????
METHYL 7-AMINOTHIENO[2,3-B]PYRAZINE-6-CARBOXYLATE
??????????? ?? ??
???( 408)?? ??
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