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[2-(?????)??]???

[2-(?????)??]???
[2-(?????)??]??? ??? ???
?? ??:
4152-92-5
???:
[2-(?????)??]???
???(??):
[2-(?????)??]???
???:
[2-(aminomethyl)phenyl]methanol
???(??):
RARECHEM GT HW 0287;UKRORGSYN-BB BBV-182531;o-(Hydroxymethyl)benzylamine;[2-(aminomethyl)phenyl]methanol
CBNumber:
CB01594964
???:
C8H11NO
??? ??:
137.18
MOL ??:
4152-92-5.mol

[2-(?????)??]??? ??

?? ?
271℃
??
1.113
???
118℃
?? ??
under inert gas (nitrogen or Argon) at 2–8 °C
?? ?? (pKa)
14.28±0.10(Predicted)

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[2-(aminomethyl)phenyl]methanol can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

Synthesis

(4-Aminomethyl-phenyl)-methanol hydrochloride salt 4-Hydroxymethyl-benzonitrile (2.0 g, 15 mol) was reduced using Raney nickel (0. 5g) and hydrogen (50 psi) in MeOH: NH3 (100ml) for 20 hours. The reaction mixture was filtered through a pad of celite. The filtrate was concentrated under reduced pressure to afford (4-aminomethyl-phenyl)-methanol hydrochloride salt (2.01 g, 98percent) as a white solid of sufficient purity for use without further purification: MS (APCI+) : m/z 138.3 (M+H).

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