2-ニトロフルオレン 化學(xué)特性,用途語(yǔ),生産方法
外観
僅かにうすい黃色～黃色、結(jié)晶性粉末～粉末
溶解性
エタノール及びアセトンに溶け、水にほとんど溶けない。
用途
有機(jī)合成原料。
用途
合成中間體、実験用発がん物質(zhì)
化學(xué)的特性
cream powder
使用
2-Nitrofluorene is a genotoxic compound and also a biomaker that affects the DNA of living organisms. An environmental pollutant.
定義
ChEBI: A nitroarene that is fluorene substituted by a nitro group at position 2.
一般的な説明
Cream-colored solid.
空気と水の反応
Insoluble in water.
反応プロフィール
Aromatic nitro compounds, such as 2-Nitrofluorene, range from slight to strong oxidizing agents. If mixed with reducing agents, including hydrides, sulfides and nitrides, they may begin a vigorous reaction that culminates in a detonation. The aromatic nitro compounds may explode in the presence of a base such as sodium hydroxide or potassium hydroxide even in the presence of water or organic solvents. The explosive tendencies of aromatic nitro compounds are increased by the presence of multiple nitro groups. Stable under normal conditions. Protect from bases.
健康ハザード
ACUTE/CHRONIC HAZARDS: Toxic. Hazardous decomposition products. Carcinogen.
安全性プロファイル
Confirmed carcinogen
with experimental carcinogenic and
tumorigenic data. Moderately toxic by
intraperitoneal route. Human mutation data
reported. When heated to decomposition it
emits toxic fumes of NOx. See also NITRO
COMPOUNDS OF AROMATIC
HYDROCARBONS.
代謝経路
Lung microsomal metabolism of 2-nitrofluorene (NF)
increases in parallel with the accumulation of P-450b
homologous mRNA and microsomal cytochrome P-
450b protein concentration. The formation of the major
metabolite, and potent mutagen, 9-hydroxy-2-
nitrofluorene (9-OHNF) is significantly inhibited by the
addition of polyclonal anti-P-450b-IgG, and by the
addition of the inhibitor, proadifen, to incubations with
lung microsomal protein.
純化方法
Crystallise 2-nitrofluorene from aqueous acetic acid or Me2CO (m 158-158.5o, also 160-160.5o). [Beilstein 5 H 628, 5 III 1948.]
2-ニトロフルオレン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品