p-アニス酸 化學(xué)特性,用途語,生産方法
外観
白色～わずかにうすい褐色, 粉末
定義
本品は、次の化學(xué)式で表される芳香族カルボン酸である。
溶解性
エタノールに溶ける。エタノール、エーテルに易溶。水には少量、熱湯には相當(dāng)量溶ける。
解説
p-アニス酸，アニスサン．ういきょう油のなかに存在するが，p-メトキシトルエンの接觸酸化やp-ヒドロキシ安息香酸のメチル化で合成できる．結(jié)晶．融點184 ℃，沸點275～280 ℃．熱水に可溶．香料の調(diào)合に保留剤として用いられる．
用途
1) 保留剤として香料の調(diào)合 2) セッケンのアルカリ中和剤として用いる。
化粧品の成分用途
pH調(diào)整剤、皮膚コンディショニング剤、香料、香味剤
説明
P-Anisic acid, also known as 4-Methoxybenzoic acid or draconic acid, is an organic acid that has a sweet flavor. It is one of the isomers of anisic acid, including m-anisic acid and o-anisic acid. The term "anisic acid" often refers to this form specifically. P-anisic acid is produced through the oxidation of p-cresyl-methyl ether.
化學(xué)的特性
It appears as a colorless needle crystal at room temperature. It is soluble in ethanol, ether, and chloroform, and only slightly soluble in hot water. It remains insoluble in cold water. It is used as an intermediate for aniracetam, as well as a preservative and fragrance.
使用
4-Methoxybenzoic acid (p-Anisic acid) is used in oxidation and reduction of cytochrome c in solution through different self-assembled monolayers on gold electrodes using cyclic voltammetry. p-Anisic acid has antiseptic properties. It is also used as an intermediate in the preparation of more complex organic compounds.
製造方法
To obtain 4-Methoxybenzoic acid, the mole ratio of cobalt and manganese is modified and p-methoxy toluene is reacted with oxygen or an oxygen-containing gas in the presence of acetic acid. The following is the experimental procedure:1. Using n-hexyl bromide, tri (n-hexyl) amine, para-methoxy toluene with cobalt chloride hexahydrate in about 9h;
2. By a catalytic oxidation process using p-methoxy toluene and propionic acid over a catalyst comprising of CoBr2.6H2O and MnBr2.4H2O with a reaction time of 20h;
3. Through changing the mole ratio of cobalt and manganese, using p-methoxy toluene with oxygen or oxygen containing gas in the presence of acetic acid to obtain the product.
定義
ChEBI: 4-methoxybenzoic acid is a methoxybenzoic acid substituted with a methoxy group at position C-4. It has a role as a plant metabolite. It is functionally related to a benzoic acid. It is a conjugate acid of a 4-methoxybenzoate.
一般的な説明
4-Methoxybenzoic acid is the sole source of carbon and energy for growth in the cultures of Nocardia sp. DSM 1069. It is effective in clearing congestion in the lungs and the respiratory tracts in conditions like asthma or bronchitis.
Biochem/physiol Actions
The cytochrome P450 enzyme CYP199A4, a heme-dependent cytochrome P450 (CYP) monooxygenase enzyme, can efficiently demethylate 4-methoxybenzoic acid. Mechanistically, O-demethylation of 4-methoxybenzoic acid occurs via hydrogen abstraction by Compound I, followed by oxygen rebound to give the hydroxylated hemiacetal which spontaneously decomposes to yield 4-hydroxybenzoic acid and formaldehyde[5].
安全性プロファイル
Poison by subcutaneous route.When heated to decomposition it emits acrid smoke andirritating vapors.
純化方法
Crystallise p-anisic acid from EtOH, water, EtOH/water or toluene. The S-benzylisothiuronium salt has m 189o (from EtOH). [Beilstein 10 II 91, 10 III 280, 10 IV 346.]
p-アニス酸 上流と下流の製品情報
原材料
準(zhǔn)備製品