DL-ERYTHRO-ジヒドロスフィンゴシン 化學(xué)特性,用途語(yǔ),生産方法
定義
本品は、次の化學(xué)式で表される有機(jī)化合物である。
化粧品の成分用途
ヘアコンディショニング剤、皮膚コンディショニング剤
説明
DL-
erythro Sphinganine (d18:0) is a precursor of ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate . Sphinganine levels increase significantly in response to certain mycotoxins, including fumonisins as well as in some cancers. This product is a mixture of sphinganine (d18:0) , L-
erythro sphinganine (d18:0) , D-
threo sphinganine (d18:0) , and L-
threo sphinganine (d18:0). [Matreya, LLC. Catalog No. 1324]
化學(xué)的特性
White Powder
使用
DL-erythro-Dihydrosphingosine is an inhibitor of PKC (protein kinase C). This compound also blocks PLA2 (phospholipases A2) and the D-sphingosine precursor.
生物學(xué)の機(jī)能
Sphingosine (Sph) is emerging as an intracellular regulator of cellular differentiation and apoptosis. Three stereoisomers,d-erythro-Sph,l-threo-Sph, and dl-erythro-dihydrosphingosine, were tested in the induction of apoptosis and inhibition of MAPK activity in three different kinds of solid tumour cell lines. d-erythro-Sph was strongest in these effects among the three compounds. l-threo-Sphingosine was partly active. On the other hand,dl-erythro-dihydrosphingosine was inactive[1].
生物活性
Protein kinase C inhibitor.
純化方法
Purify it by recrystallisation from pet ether/EtOAc or CHCl3. The (±)-N-dichloroacetyl derivative has m 142-144o (from MeOH). [Shapiro et al. J Am Chem Soc 80 2170 1958, Shapiro & Sheradsky J Org Chem 28 2157 1963.] The D-isomer crystallises from pet ether/Et2O and has m 78.5-79o, [] 28 +6o (CHCl3/MeOH, 10:1). [Grob & Jenny Helv Chim Acta 35 2106 1953, Jenny & Grob Helv Chim Acta 36 1454 1953, Beilstein 4 I 448, 4 II 757, 4 III 854, 4 IV 1887.]
DL-ERYTHRO-ジヒドロスフィンゴシン 上流と下流の製品情報(bào)
原材料
準(zhǔn)備製品