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チオストレプトン

チオストレプトン 化學(xué)構(gòu)造式
1393-48-2
CAS番號(hào).
1393-48-2
化學(xué)名:
チオストレプトン
別名:
ブリアマイシン;チオストレプトンA;チアクチン;チオストレプトン;チオストレプトン FROM STREPTOMYCES AZUREUS
英語名:
THIOSTREPTON
英語別名:
x146;a-8506;thiactin;bryamycin;hiostrepton;THIOSTREPTON;Thiostreptin;THIOSTREPTION;antibioticx146;(-)-Nuciferine
CBNumber:
CB5204768
化學(xué)式:
C72H85N19O18S5
分子量:
1664.89
MOL File:
1393-48-2.mol

チオストレプトン 物理性質(zhì)

融點(diǎn) :
248-257°C (dec.)
比旋光度 :
D23 -98.5° (glacial acetic acid); -61° (dioxane); -20° (pyridine)
比重(密度) :
1.0824 (rough estimate)
屈折率 :
1.6700 (estimate)
貯蔵溫度 :
Sealed in dry,Store in freezer, under -20°C
溶解性:
DMSOまたはクロロホルムに可溶
外見 :
オフホワイトパウダー
酸解離定數(shù)(Pka):
10.43±0.46(Predicted)
色:
オフホワイト
水溶解度 :
0.24g/L(28℃)
Merck :
13,9440
安定性::
購入日から2年間安定です。この DMSO 溶液は、-20°C で 1 週間保存できます。

安全性情報(bào)

主な危険性  Xn
Rフレーズ  22
Sフレーズ  22-24/25
WGK Germany  3
RTECS 番號(hào) XN6300100
10-21
HSコード  29419090
毒性 LD50 oral in mouse: > 1gm/kg

チオストレプトン 価格 もっと(9)

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購入
富士フイルム和光純薬株式會(huì)社(wako) W01LKTT3134
Thiostrepton
1393-48-2 100mg ¥11600 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01LKTT3134
Thiostrepton
1393-48-2 500mg ¥31600 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01LKTT3134 チオストレプトン
Thiostrepton
1393-48-2 1g ¥54800 2024-03-01 購入
富士フイルム和光純薬株式會(huì)社(wako) W01LKTT3134 チオストレプトン
Thiostrepton
1393-48-2 5g ¥215800 2024-03-01 購入
Sigma-Aldrich Japan T8902 チオストレプトン from Streptomyces azureus ≥90% (HPLC)
Thiostrepton from Streptomyces azureus ≥90% (HPLC)
1393-48-2 1g ¥41800 2024-03-01 購入

チオストレプトン 化學(xué)特性,用途語,生産方法

効能

抗生物質(zhì) (獣醫(yī)薬)

説明

The mammalian transcription factor forkhead box M1 (FoxM1) is induced during G1 phase, with expression continuing through S phase and mitosis. Thiostrepton is a natural peptide thiazole antibiotic that inhibits FoxM1 in mammalian cells, preventing the expression of FoxM1-regulated genes, which includes FoxM1 itself. Through this mechanism, thiostrepton prevents proliferation and induces apoptosis in human cancer cells. These effects correlate with the ability of thiostrepton to act as a proteasome inhibitor.

化學(xué)的特性

Off-White Solid

使用

Thiostrepton is a macrocyclic antibiotic incorporating thiazoles and other atypical amino acids. Patented in 1961, thiostrepton has been used as an antibiotic and acts by binding to ribosomes to prevent the binding of the EF-G elongation factor and GTP to the 50S ribosomal subunit. Thiostrepton is an inducer of tipA, a gene that controls the bacterial transcription regulators, TipAL and TipAS, that are central regulators in multidrug resistance. Thiostrepton is closely related to siomycin, a recently discovered inhibitor of oncogenic transcription factor, FoxM1.

定義

ChEBI: A heterodetic cyclic peptide, in which the cyclisation step involves a formal lactonisation between the carboxy group of a quinaldic acid-based residue and a secondary alcohol. An antibiotic that inhibits bacterial protein synthesis. Also acts as an antitu or agent.

一般的な説明

A thiazole-containing peptide antibiotic that inhibits protein synthesis by preventing binding of GTP to 50S ribosomal subunit. Inhibits the function of elongation factor G (EF-G) and the dissociation of EF-G from the ribosome. The thiostrepton-resistant gene is also commonly used as a selective marker for recombinant DNA/plasmid technologies.

チオストレプトン 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品


チオストレプトン 生産企業(yè)

Global( 172)Suppliers
名前 電話番號(hào) 電子メール 國籍 製品カタログ 優(yōu)位度
Hebei Chuanghai Biotechnology Co., Ltd
+86-15531157085 +86-15531157085
abby@chuanghaibio.com China 8805 58
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12824 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19552 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49732 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32159 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30231 58
HONG KONG IPURE BIOLOGY CO.,LIMITED
86 18062405514 18062405514
ada@ipurechemical.com CHINA 3461 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
86-571-88216897,88216896 13588875226
sales@hzclap.com CHINA 6312 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58

チオストレプトン  スペクトルデータ(MS)


1393-48-2(チオストレプトン)キーワード:


  • 1393-48-2
  • Thiostrepton (200 mg)
  • BryaMycin, Thiactin, AlaninaMide, X 146, A 8506, 6761-31
  • Thiostrepton, froM StreptoMyces sp.
  • x146
  • THIOSTREPTON
  • Alaninamide, L-threonyl-(4S)-2-(1Z)-1-amino-1-propenyl-4,5-dihydro-4-thiazolecarbonyl-2-(1S,2S,3R)-1-amino-2,3-dihydroxy-2-methylbutyl-4-thiazolecarbonyl-2-(5R,6S)-6-2-(1S,2R)-1-amino-2-hydroxypropyl-4-thiazolyl-5-N-(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy
  • THIOSTREPTION
  • thiostrepton from streptomyces azureus
  • AlaninaMide,N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-aMino-21-[(1S,2R)-1,2-dihydroxy-1-Methylpropyl]-14-ethylidene-3,4,4a,9,10,1
  • a-8506
  • antibiotic6761-31
  • antibiotica8506
  • antibioticx146
  • bryamycin
  • thiactin
  • Thiostrepton, 96%, from Streptomyces sp.
  • Thiostrepton - CAS 1393-48-2 - Calbiochem
  • Alaninamide, N-[(7R,8S)-2-carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahyd...
  • THIOSTREPTON USP/EP/BP
  • N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroalanyl-2,3-didehydro-alaninamide,(1→528)-lactone
  • (-)-Nuciferine
  • hiostrepton
  • Thiostrepton, USP
  • Thiostreptin
  • N-[(7R,8S)-2-Carboxy-7,8-dihydro-8-hydroxy-4-[(1S)-1-hydroxyethyl]-7-quinolinyl]-L-isoleucyl-L-alanyl-2,3-didehydroalanyl-L-alanyl-2-[(4aR,11S,14Z,18S,21S,28S,32aS)-4a-amino-21-[(1S,2R)-1,2-dihydroxy-1-methylpropyl]-14-ethylidene-3,4,4a,9,10,11,12,13,14,18,19,20,21,27,28,32a-hexadecahydro-11,28-bis[(1R)-1-hydroxyethyl]-9,12,19,26-tetraoxo-17H,26H-8,5:18,15:25,22:32,29-tetranitrilo-5H,15H-pyrido[3,2-m][1,11,17,24,4,7,20,27]tetrathiatetraazacyclotriacontin-2-yl]-4-thiazolecarbonyl-2,3-didehydroala
  • Thiostrepton, 10 mM in DMSO
  • THIOSTREPTON USP (NON-STERILE BULK FORM)
  • ブリアマイシン
  • チオストレプトンA
  • チアクチン
  • チオストレプトン
  • チオストレプトン FROM STREPTOMYCES AZUREUS
  • ペプチド系抗生物質(zhì)
  • 抗細(xì)菌薬
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