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リバビリン

リバビリン 化學(xué)構(gòu)造式
36791-04-5
CAS番號.
36791-04-5
化學(xué)名:
リバビリン
別名:
リバビリン;1-[3-(アミノカルボニル)-1H-1,2,4-トリアゾール-1-イル]-1-デオキシ-β-D-リボフラノース;ビラミド;コペガス;リバミジル;ビラゾール;1-β-D-リボフラノシル-1H-1,2,4-トリアゾール-3-カルボアミド;ビロナ;リバミド;1-(β-D-リボフラノシル)-3-カルバモイル-1H-1,2,4-トリアゾール;1-(β-D-リボフラノシル)-1H-1,2,4-トリアゾール-3-カルボアミド;レベトール;リバビリン標(biāo)準(zhǔn)品;1-(β-D-リボフラノシル)-1,2,4-トリアゾール-3-カルボキサミド;リバビリン (JP17);1-[(2R,3R,4S,5R)-3,4-ジヒドロキシ-5-(ヒドロキシメチル)オキソラン-2-イル]-1H-1,2,4-トリアゾール-3-カルボキサミド
英語名:
Ribavirin
英語別名:
RTC;VIRAZOLE;LEVOVIRIN;RIBAVARIN;Ribavirine;REBETOL;Copegus;tribavirin;Ribasphere;rtca
CBNumber:
CB0689324
化學(xué)式:
C8H12N4O5
分子量:
244.21
MOL File:
36791-04-5.mol
MSDS File:
SDS

リバビリン 物理性質(zhì)

融點(diǎn) :
174-176°C
比旋光度 :
D25 -36.5° (c = 1 in water); D20 -38° (c = 1 in water)
沸點(diǎn) :
387.12°C (rough estimate)
比重(密度) :
1.4287 (rough estimate)
屈折率 :
-36 ° (C=1, H2O)
貯蔵溫度 :
2-8°C
溶解性:
水に溶けやすく、エタノール (96%) に溶けにくく、ジクロロメタンに溶けにくい。ポリモーフィズム (5.9) を示します。
外見 :
白い固體
酸解離定數(shù)(Pka):
12.95±0.70(Predicted)
色:
白い
水溶解度 :
>=10 g/100 mL で 19 ºC
Merck :
14,8198
BCS Class:
3
安定性::
DMSOまたは蒸留水の溶液で-20°Cで最大3か月保存できます.
InChIKey:
IWUCXVSUMQZMFG-AFCXAGJDSA-N
LogP:
-2.260 (est)
CAS データベース:
36791-04-5
EPAの化學(xué)物質(zhì)情報(bào):
Ribavirin (36791-04-5)
安全性情報(bào)
  • リスクと安全性に関する聲明
  • 危険有害性情報(bào)のコード(GHS)
主な危険性  T,Xi
Rフレーズ  61-36/38
Sフレーズ  53-22-45-37/39-26
WGK Germany  3
RTECS 番號 XZ4250000
HSコード  29349990
有毒物質(zhì)データの 36791-04-5(Hazardous Substances Data)
毒性 LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)
化審法 (9)-1515
絵表示(GHS) GHS hazard pictograms
注意喚起語 危険
危険有害性情報(bào)
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語 シンボル P コード
H341 遺伝性疾患のおそれの疑い 生殖細(xì)胞変異原性 2 警告 P201,P202, P281, P308+P313, P405,P501
注意書き
P201 使用前に取扱説明書を入手すること。
P308+P313 暴露または暴露の懸念がある場合:醫(yī)師の診斷/手當(dāng)てを 受けること。

リバビリン 価格 もっと(38)

メーカー 製品番號 製品説明 CAS番號 包裝 価格 更新時(shí)間 購入
富士フイルム和光純薬株式會社(wako) W01TRCR414475 リバビリン
Ribavirin
36791-04-5 10mg ¥20400 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01TRCR414475 リバビリン
Ribavirin
36791-04-5 50mg ¥22200 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01MAS075767 リバビリン
Ribavirin
36791-04-5 25g ¥23000 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01COBOT-0885 リバビリン
Ribavirin
36791-04-5 25g ¥10000 2024-03-01 購入
富士フイルム和光純薬株式會社(wako) W01COBOT-0885 リバビリン
Ribavirin
36791-04-5 5g ¥10000 2024-03-01 購入

リバビリン 化學(xué)特性,用途語,生産方法

外観

白色~ほとんど白色粉末~結(jié)晶

用途

ウィルス RNA ポリメラーゼ を阻害し、ウィルスの増殖阻害作用を示しま す。

用途

リバビリン(Ribavirin)は、抗ウイルス薬の一つで、主にC型肝炎やウイルス性出血熱等の治療で施行されている。

効能

抗ウイルス薬

商品名

コペガス (中外製薬); レベトール (MSD)

化學(xué)的特性

Colourless Solid

使用

Ribavirin is a guanosine analog with antiviral properties against DNA and RNA viruses, including respiratory syncytial virus, hepatitis C, and influenza. It acts as a prodrug that can be activated by either mono- or tri-phosphorylation by cellular kinases. These phosphorylated derivatives of ribavirin have diverse effects on both cellular and viral enzymes, resulting in suppression of viral replication.

定義

ChEBI: A 1-ribosyltriazole that is the 1-ribofuranosyl derivative of 1,2,4-triazole-3-carboxamide. An inhibitor of HCV polymerase.

適応癥

Ribavirin is a synthetic guanosine analogue that possesses broad antiviral inhibitory activity against many viruses, including influenza A and B, parainfluenza,RSV, HCV, HIV-1, and various herpesviruses, arenaviruses, and paramyxoviruses. Its exact mechanism of action has not been fully elucidated; however, it appears to inhibit the synthesis of viral mRNA through an effect on nucleotide pools. Following absorption, host cell enzymes convert ribavirin to its monophosphate, diphosphate, and triphosphate forms. Ribavirin monophosphate inhibits the guanosine triphosphate (GTP) synthesis pathway and subsequently inhibits many GTP-dependent processes. Ribavirin triphosphate inhibits the 5 capping of viral mRNA with GTP and specifically inhibits influenza virus RNA polymerase. Ribavirin may also act by increasing the mutation rate of RNA viruses, leading to the production of nonviable progeny virions. Ribavirin resistance has not been documented in clinical isolates.

獲得抵抗性

Development of resistant virus strains has not been demonstrated.

一般的な説明

Ribavirin is 1-β-D-ribofuranosyl-1,2,4-thiazole-3-carboxamide.The compound is a purine nucleoside analog with amodified base and a D-ribose sugar moiety.
Ribavirin inhibits the replication of a very wide variety ofRNA and DNA viruses,68 including orthomyxoviruses,paramyxoviruses, arenaviruses, bunyaviruses, herpesviruses,adenoviruses, poxvirus, vaccinia, influenza virus(types A and B), parainfluenza virus, and rhinovirus. In spiteof the broad spectrum of activity of ribavirin, the drug hasbeen approved for only one therapeutic indication—thetreatment of severe lower respiratory infections caused byRSV in carefully selected hospitalized infants and youngchildren.

空気と水の反応

Water soluble.

反応プロフィール

Ribavirin may be sensitive to prolonged exposure to light.

危険性

Mildly toxic by ingestion. An experimental teratogen.

火災(zāi)危険

Flash point data for Ribavirin are not available; however, Ribavirin is probably combustible.

応用例(製薬)

A synthetic nucleoside. It is neither a classic pyrimidine nor a purine, but stereochemical studies indicate that it is a guanosine analog. It is usually formulated for administration by inhalation, but oral and intravenous preparations are also used.

作用機(jī)序

Ribavirin, a guanosine analogue, has broad-spectrum antiviral activity against both DNA and RNA viruses. It is phosphorylated by adenosine kinase to the triphosphate, resulting in the inhibition of viral specific RNA polymerase, disrupting messenger RNA and nucleic acid synthesis.

薬理學(xué)

Oral and intravenous ribavirin are associated with additional adverse effects.When given via these routes, ribavirin can produce hemolytic anemia that is reversible following dosage reduction or cessation of therapy. When given in combination with interferon- , ribavirin increases the incidence of many of its side effects, such as fatigue, nausea, insomnia, depression, and anemia, and may cause fatal or nonfatal pancreatitis. Ribavirin is mutagenic, teratogenic, and embryotoxic in animals at doses below the therapeutic level in humans. It is contraindicated in pregnant women and in the male partners of pregnant women. Women of childbearing potential and male partners of these women must use two effective forms of contraception during ribavirin treatment and for 6 months post therapy. Pregnant women should not directly care for patients receiving ribavirin.

臨床応用

Ribavirin aerosol (Virazole) is indicated in the treatment of high-risk infants and young children with severe bronchiolitis or pneumonia due to RSV infection. Treatment is most effective if begun within 3 days of the onset of symptoms.
Although ribavirin monotherapy is ineffective against HCV, oral ribavirin in combination with interferon-α (Rebatron) is approved for this indication and is effective in patients resistant to interferon therapy alone. Intravenous ribavirin may be useful in the therapy of Hantaan virus infection, Crimean or Congo virus hemorrhagic fever, Lassa fever, and severe adenovirus infection.

副作用

Most adverse effects associated with aerosol ribavirin are local. Pulmonary function may decline if aerosol ribavirin is used in adults with chronic obstructive lung disease or asthma. Deterioration of pulmonary and cardiovascular function has also been seen in severely ill infants given this preparation. Rash, conjunctivitis, and rare cases of anemia have been reported. Health care workers exposed to aerosol ribavirin during its administration have reported adverse effects including headache, conjunctivitis, rash, and rarely, bronchospasm.

リバビリン 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品


リバビリン 生産企業(yè)

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リバビリン  スペクトルデータ(1HNMR)


36791-04-5(リバビリン)キーワード:


  • 36791-04-5
  • RIBAVIRIN
  • rtca
  • vilona
  • VIRAMID
  • VIRAZID
  • 1-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CAROXAMIDE
  • 1-BETA-D-RIBOFURANOSYL-1H-1,2,4-TRIAZOLE-3-CARBOXAMIDE
  • 1-BETA-D-RIBOFURANOSYL-1,2,4-TRIAZOLE-3-CARBOXAMIDE
  • biopolymers
  • ICN-1229
  • RibavirinGmp/Edmf
  • RibavirinGmp/EdmfUsp29
  • 1-b-D-Ribofuranosyl-1H-1,2,4-triazole-3-carboxamide
  • 1H-1,2,4-Triazole-3-carboxamide, 1-.beta.-D-ribofuranosyl-
  • 1-((2R,3R,4S,5R)-3,4-DIHYDROXY-5-HYDROXYMETHYL-TETRAHYDRO-FURAN-2-YL)-1H-[1,2,4]TRIAZOLE-3-CARBOXYLIC ACID AMIDE
  • 1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxyMethyl)tetrahydrofuran-2-yl)-1H-1,2,4-triazole-3-carboxaMide
  • USP, EP, BP
  • ICN-1229 ,RTCA
  • 1-(3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-1H-[1,2,4]triazole-3-carboxylic acid amide
  • 1h-1,2,4-triazole-3-carboxamide, 1--d-ribofuranosyl-
  • Ribavirin (Copegus)
  • Ribavirin solution,100ppm
  • Ribavirin, >=98%
  • 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-1H-1,2,4-triazole-3-carboxamide
  • Ribovirin
  • 1--D-ribafuranosyl-1H-1,2,4-triazole-3-carboxamide
  • Ribavirin antiviral
  • Ribavirin, Antibiotic for Culture Media Use Only
  • Ribavirin≥98%(HPLC)
  • D-RIBAVIRIN
  • リバビリン
  • 1-[3-(アミノカルボニル)-1H-1,2,4-トリアゾール-1-イル]-1-デオキシ-β-D-リボフラノース
  • ビラミド
  • コペガス
  • リバミジル
  • ビラゾール
  • 1-β-D-リボフラノシル-1H-1,2,4-トリアゾール-3-カルボアミド
  • ビロナ
  • リバミド
  • 1-(β-D-リボフラノシル)-3-カルバモイル-1H-1,2,4-トリアゾール
  • 1-(β-D-リボフラノシル)-1H-1,2,4-トリアゾール-3-カルボアミド
  • レベトール
  • リバビリン標(biāo)準(zhǔn)品
  • 1-(β-D-リボフラノシル)-1,2,4-トリアゾール-3-カルボキサミド
  • リバビリン (JP17)
  • 1-[(2R,3R,4S,5R)-3,4-ジヒドロキシ-5-(ヒドロキシメチル)オキソラン-2-イル]-1H-1,2,4-トリアゾール-3-カルボキサミド
  • 生化學(xué)
  • 試験研究用抗ウィルス剤
  • 試験研究用抗菌剤
  • 薬理研究用試薬
  • ヌクレオシド,ヌクレオチド&関連試薬
  • ヌクレオシドと類似體
  • 抗ウイルス薬
  • 生活関係標(biāo)準(zhǔn)物質(zhì)
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