ChemicalBook >> CAS DataBase List >>BIX 01294
BIX 01294
- CAS No.
- 1392399-03-9
- Chemical Name:
- BIX 01294
- Synonyms
- CS-1418;BIX 01204;BIX01294 HCl;BIX01294 triHCl;BIX 01294 USP/EP/BP;BIX01294 hydrochloride;BIX01294 3hydrochloride;Trihydrochloride Hydrate;BIX 01294 Trihydrochloride Hydrate;BIX01294 hydrochloride BIX-01294 HCL
- CBNumber:
- CB92677401
- Molecular Formula:
- C28H41Cl3N6O2
- Molecular Weight:
- 600.02314
- MDL Number:
- MFCD16618384
- MOL File:
- 1392399-03-9.mol
Last updated:2024-11-17 16:00:36
| storage temp. | Inert atmosphere,2-8°C |
|---|---|
| solubility | H2O: >20mg/mL |
| form | powder |
| color | white |
| FDA UNII | 57HBY4AC4W |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | 3 |
| HS Code | 2933.99.8290 |
BIX 01294 price More Price(13)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B9311 | BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder | 1392399-03-9 | 5mg | $221 | 2024-03-01 | Buy |
| Sigma-Aldrich | B9311 | BIX 01294 trihydrochloride hydrate ≥98% (HPLC), powder | 1392399-03-9 | 25mg | $525 | 2024-03-01 | Buy |
| TCI Chemical | B4211 | BIX 01294 Trihydrochloride Hydrate >85.0%(N) | 1392399-03-9 | 25mg | $608 | 2024-03-01 | Buy |
| TRC | B591600 | BIX01294Trihydrochloride | 1392399-03-9 | 250mg | $1175 | 2021-12-16 | Buy |
| Biosynth Carbosynth | BB162787 | BIX 01294 | 1392399-03-9 | 50mg | $437.5 | 2021-12-16 | Buy |
BIX 01294 Chemical Properties,Uses,Production
Uses
BIX 01294 trihydrochloride hydrate has been used:
- as a histone methylation inhibitor to treat E4 cells for analysing green fluorescent protein (d2EGFP) expression
- to investigate the role of G9a in neuroblastoma tumor growth
- as specific inhibitor of G9a to treat the SK-N-AS, BE(2)-C, SK-N-DZ, SK-N-F1, and SHEP1 neuroblastoma cell lines
General Description
BIX-01294, a diazepin-quinazolinamine derivative, is a histone-lysine methyltransferase (HMTase) inhibitor that modulates the epigenetic status of chromatin. BIX-01294 inhibits the G9aHMTase dependent levels of histone-3 lysine (9) methylation (H3K9me). Bix-01294 and valproic acid, a histone deacetylase (HDAC) inhibitor, may replace the requirement for ectopic OCT4 (POU5F1) and cMyc respectively in pluripotent stem cell induction (iPS) recipes.
Biochem/physiol Actions
BIX 01294 is a selective histone methyl transferase inhibitor. In its inhibition of the histone lysine methyltransferases, BIX 01294 does not compete with cofactor S-adenosyl-methionine. The target enzyme is G9a, and it selectively impairs G9a HMTase and the generation of H3K9me2 in vitro.
storage
room temperature (desiccate)
BIX 01294 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 87)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32951 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32112 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 22883 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
View Lastest Price from BIX 01294 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | BIX-01294 trihydrochloride
1392399-03-9
|
US $37.00-65.00 / mg | 99.95% | 10g | TargetMol Chemicals Inc. |
-
- BIX-01294 trihydrochloride
1392399-03-9
- US $37.00-65.00 / mg
- 99.95%
- TargetMol Chemicals Inc.
BIX 01294 Trihydrochloride Hydrate
4-Quinazolinamine, 2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-, hydrochloride (1:3)
2-(Hexahydro-4-Methyl-1H-1,4-Diazepin-1-yl)-6,7-Dimethoxy-[1-(Phenylmethyl)-4-Piperidynyl]-4-Quinazolinamine Trihydrochloride BIX01294 hydrochloride
BIX01294 hydrochloride
BIX01294 3hydrochloride
Trihydrochloride Hydrate
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine
BIX 01204
CS-1418
N-(1-benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine hydrochloride
N-(1-Benzyl-4-piperidinyl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan -1-yl)-4-quinazolinamine trihydrochloride
BIX 01294 Trihydrochloride Hydrate>
BIX01294 HCl
BIX 01294 USP/EP/BP
N-(1-Benzylpiperidin-4-yl)-6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)quinazolin-4-amine trihydrochloride
BIX01294 triHCl
BIX01294 hydrochloride BIX-01294 HCL
SUV39H1(H320R),BIX-01294 trihydrochloride,p21,recurrent,Cdkn1a,MLKL,H3K9me3,inhibit,Histone Methyltransferase,PRMT1,p53,Autophagy,Inhibitor,H3K9me2,BIX 01294 trihydrochloride,Gadd45a,BIX01294 trihydrochloride
1392399-03-9
C28H38N6O23HClxH2O
Inhibitors