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ChemicalBook >> CAS DataBase List >>6-Nitroindazole

6-Nitroindazole

CAS No.
7597-18-4
Chemical Name:
6-Nitroindazole
Synonyms
6-NITRO-1H-INDAZOLE;6-Nitrobrazol;6-NITROINDAZOLE;6-Nitroindazoles;6-Nitroisoindazole;6-nitro-1h-indazol;6-Nitroindazole>6-Nitroindazole 97%;6-Nitroindazole,98%;6-Nitroindazole ,97%
CBNumber:
CB8358413
Molecular Formula:
C7H5N3O2
Molecular Weight:
163.13
MDL Number:
MFCD00005695
MOL File:
7597-18-4.mol
MSDS File:
SDS
Last updated:2024-12-18 14:15:30

6-Nitroindazole Properties

Melting point 180-182 °C (lit.)
Boiling point 290.19°C (rough estimate)
Density 1.4141 (rough estimate)
refractive index 1.5500 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility very faint turbidity in hot Methanol
form Powder
pka 11.08±0.40(Predicted)
color Light Yellow
BRN 7812
CAS DataBase Reference 7597-18-4(CAS DataBase Reference)
EWG's Food Scores 1
NIST Chemistry Reference 6-Nitroindazole(7597-18-4)
EPA Substance Registry System 1H-Indazole, 6-nitro- (7597-18-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302+H312+H332-H315-H319-H335-H351
Precautionary statements  P280-P301+P312-P302+P352+P312-P304+P340+P312-P305+P351+P338-P308+P313
Hazard Codes  Xn,Xi
Risk Statements  20/21/22-36/37/38-40-68-36
Safety Statements  26-27-36/37/39
WGK Germany  3
RTECS  NK7962100
TSCA  Yes
HS Code  29339900
NFPA 704
0
1 0

6-Nitroindazole price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich N17513 6-Nitroindazole 97% 7597-18-4 100g $254 2023-06-20 Buy
TCI Chemical N0399 6-Nitroindazole >98.0%(GC) 7597-18-4 25g $34 2024-03-01 Buy
TCI Chemical N0399 6-Nitroindazole >98.0%(GC) 7597-18-4 250g $167 2024-03-01 Buy
Alfa Aesar A16213 6-Nitro-1H-indazole, 97% 7597-18-4 100g $88 2021-12-16 Buy
Alfa Aesar A16213 6-Nitro-1H-indazole, 97% 7597-18-4 25g $35.8 2021-12-16 Buy
Product number Packaging Price Buy
N17513 100g $254 Buy
N0399 25g $34 Buy
N0399 250g $167 Buy
A16213 100g $88 Buy
A16213 25g $35.8 Buy

6-Nitroindazole Chemical Properties,Uses,Production

Description

6-Nitroindazole is a competitive and reversible Monoamine oxidase(MAO)inhibitor. It can inhibit MAO-A and MAO-B (IC50= 2.5 μM). Monoamine oxidase (MAO) B is a mitochondrial enzyme selectively involved in the oxidative activation of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to toxic pyridinium cations producing Parkinsonism in animal models. In addition, it is an nNOS inhibitor, which has neuroprotective effects[1].

Chemical Properties

yellow powder

Uses

Anticonvulsant.

Synthesis

6-Nitroindazole is prepared by (2-methyl-5-nitrophenyl)azo phenyl sulfide and 1,8-diazabicyclo[5.4.0]undec-7-ene in the presence of concentrated  acetonitrile.6-Nitroindazole

References

[1] HERRAIZTOMAS  GuillénHugo  AránVicente J. Nitroindazole compounds inhibit the oxidative activation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxin to neurotoxic pyridinium cations by human monoamine oxidase (MAO).[J]. Free Radical Research, 2009: 975-984. DOI:10.1080/10715760903159170.

99-55-8
7597-18-4
Synthesis of 6-Nitroindazole from 2-Methyl-5-nitroaniline
Global( 325)Suppliers
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Shaanxi Dideu Medichem Co. Ltd 		+86-29-81148696 +86-15536356810 1022@dideu.com China 3882 58
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View Lastest Price from 6-Nitroindazole manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
6-Nitro-1H-indazole pictures 2024-12-21 6-Nitro-1H-indazole
7597-18-4
 US $0.00-0.00 / kg 1kg ≥98% by HPLC 100kg/month Zison Pharmaceutical (Shandong) Co., Ltd.
6-Nitroindazole pictures 2024-11-26 6-Nitroindazole
7597-18-4
 US $0.00-0.00 / kg 1kg 98% 1 ton Nanjing Fred Technology Co., Ltd
6-Nitroindazole pictures 2024-11-05 6-Nitroindazole
7597-18-4
 US $0.00-0.00 / KG 1g 99% 2000tons Shaanxi Dideu Medichem Co. Ltd
  • 6-Nitro-1H-indazole pictures
  • 6-Nitro-1H-indazole
    7597-18-4
  • US $0.00-0.00 / kg
  • ≥98% by HPLC
  • Zison Pharmaceutical (Shandong) Co., Ltd.
  • 6-Nitroindazole pictures
  • 6-Nitroindazole
    7597-18-4
  • US $0.00-0.00 / kg
  • 98%
  • Nanjing Fred Technology Co., Ltd
  • 6-Nitroindazole pictures
  • 6-Nitroindazole
    7597-18-4
  • US $0.00-0.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
1H-Indazole, 6-nitro- 6-nitro-1h-indazol 6-Nitroisoindazole 6-NITROINDAZOLE 6-Nitro-1(2)H-indazole 6-Nitroindazole ,97% 6-Nitroindazole,98% 6-Nitroindazoles 6-Nitro-1H-indazole,97% 6-Nitroindazole 97% 6-Nitroindazole> 6-Nitrobrazol Pazopanib Impurity 59 6-NITRO-1H-INDAZOLE N-(2-methoxypyrimidin-4-yl)-N,2,3-trimethyl-2H-indazol-6-aminediamine Axitinib Impurity N22 7597-18-4 9597-18-4 Building Blocks Heterocyclic Building Blocks Indazoles Inhibitors Nitric Oxide Reagents Building Blocks Heterocyclic Building Blocks Heterocyclic Compounds All Inhibitors Indazoles Intermediate