ChemicalBook >> CAS DataBase List >>4-Fluorobenzaldehyde
4-Fluorobenzaldehyde
- CAS No.
- 459-57-4
- Chemical Name:
- 4-Fluorobenzaldehyde
- Synonyms
- PFBA;P-FLUOROBENZALDEHYDE;PFAD;Benzaldehyde, 4-fluoro-;NSC 68095;JACS-459-57-4;AKOS BBS-00003166;4-Fluorbenzaldehyd;P-FLUORBENZALDEHYDE;p-Fluoro benzaldehy
- CBNumber:
- CB6299747
- Molecular Formula:
- C7H5FO
- Molecular Weight:
- 124.11
- MDL Number:
- MFCD00003378
- MOL File:
- 459-57-4.mol
- MSDS File:
- SDS
Last updated:2024-12-18 14:15:30
| Melting point | -10 °C (lit.) |
|---|---|
| Boiling point | 181 °C/758 mmHg (lit.) |
| Density | 1.157 g/mL at 25 °C (lit.) |
| vapor pressure | 19 hPa (70 °C) |
| refractive index |
n |
| Flash point | 134 °F |
| storage temp. | Store below +30°C. |
| solubility | Chloroform, Methanol |
| form | Liquid |
| Specific Gravity | 1.157 |
| color | Clear colorless to yellow |
| Water Solubility | IMMISCIBLE |
| Sensitive | Air Sensitive |
| BRN | 385857 |
| Stability | Air Sensitive |
| InChIKey | UOQXIWFBQSVDPP-UHFFFAOYSA-N |
| CAS DataBase Reference | 459-57-4(CAS DataBase Reference) |
| FDA UNII | N8681893GA |
| NIST Chemistry Reference | Benzaldehyde, 4-fluoro-(459-57-4) |
| EPA Substance Registry System | Benzaldehyde, 4-fluoro- (459-57-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H226-H315-H319-H335 | |||||||||
| Precautionary statements | P210-P233-P240-P241-P303+P361+P353-P305+P351+P338 | |||||||||
| Hazard Codes | Xi,F | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36-37/39-36/37/39-27 | |||||||||
| RIDADR | UN 1989 3/PG 3 | |||||||||
| WGK Germany | 2 | |||||||||
| F | 9-23 | |||||||||
| Hazard Note | Flammable | |||||||||
| TSCA | T | |||||||||
| HazardClass | 3.2 | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29130000 | |||||||||
| NFPA 704 |
|
4-Fluorobenzaldehyde price More Price(32)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 128376 | 4-Fluorobenzaldehyde 98% | 459-57-4 | 10g | $29.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | 128376 | 4-Fluorobenzaldehyde 98% | 459-57-4 | 50g | $76.9 | 2024-03-01 | Buy |
| Sigma-Aldrich | 8.18537 | 4-Fluorobenzaldehyde for synthesis | 459-57-4 | 25mL | $51.5 | 2023-01-07 | Buy |
| TCI Chemical | F0191 | 4-Fluorobenzaldehyde >98.0%(GC) | 459-57-4 | 25mL | $32 | 2024-03-01 | Buy |
| TCI Chemical | F0191 | 4-Fluorobenzaldehyde >98.0%(GC) | 459-57-4 | 250mL | $183 | 2024-03-01 | Buy |
4-Fluorobenzaldehyde Chemical Properties,Uses,Production
Chemical Properties
Clear colorless to yellow liquid
Uses
Usually used in the preparation of pyrazolopyridine UR-13756.
Uses
4-Fluorobenzaldehyde is a fluorinated benzaldehyde with inhibitory activity of mushroom tyrosinase. 4-Fluorobenzaldehyde is commonly used as a synthetic intermediate in the preparation of pharmaceutic al compounds.
Uses
4-Fluorobenzaldehyde is used in the preparation of pyrazolopyridine derivative, which finds application as mitogen-activated protein kinase (MAPK) inhibitor. It also serves as a synthetic intermediate in the preparation of pharmaceutical compounds.
Synthesis
4-Fluorobenzaldehyde is produced by a commercially feasible process. The process comprises heating a mixture of fluorobenzene and a strong Lewis acid with dissolved hydrogen halide in an atmosphere of carbon monoxide at about 45 to about 100° C. and at a total pressure of about 150 psig up to the maximum pressure rating of the reactor. Formed is a reaction mass containing a Lewis acid complex of 4-fluorobenzaldehyde and at least a halobis(fluorophenyl)methane by-product. The complex is broken by quenching the reaction mass with a Lewis acid-solvating liquid to liberate 4-fluorobenzaldehyde. By-product halobis(fluorophenyl)methane is converted to di(fluorophenyl)methanol to avoid potential corrosion problems and formation of light-sensitive color bodies in the recovered 4-fluorobenzaldehyde.
4-Fluorobenzaldehyde Preparation Products And Raw materials
Raw materials
Preparation Products
4-N-PROPOXYBENZALDEHYDE
4-Pyrazol-1-yl-benzaldehyde
3-Bromo-4-fluorobenzaldehyde
2-[2-(4-Fluorophenyl)-2-oxo-1-phenylethyl]-4-methyl-3-oxo-N-phenylpentanamide
4-Fluorobenzoic acid
(5-Fluoro-2-methyl-1H-inden-3-yl)acetic acid
Rosiglitazone
4-Fluorocinnamic acid
DL-3-(4-Fluorophenyl)alanine
4-(1H-Imidazol-1-yl)benzaldehyde
1of4
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View Lastest Price from 4-Fluorobenzaldehyde manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-12-20 | 4-Fluorobenzaldehyde
459-57-4
|
US $70.00-25.00 / kg | 1kg | 99% | 20ton | Hebei Zhuanglai Chemical Trading Co.,Ltd | |
 |
2024-12-12 | 4-Fluorobenzaldehyde
459-57-4
|
US $6.00-1.00 / kg | 1kg | 99% | 300tons | Hebei Dangtong Import and export Co LTD | |
 |
2024-10-28 | 4-Fluorobenzaldehyde
459-57-4
|
US $1.00 / KG | 1KG | 99% | 10 mt | Hebei Weibang Biotechnology Co., Ltd |
-
- 4-Fluorobenzaldehyde
459-57-4
- US $70.00-25.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co.,Ltd
-
- 4-Fluorobenzaldehyde
459-57-4
- US $6.00-1.00 / kg
- 99%
- Hebei Dangtong Import and export Co LTD
-
- 4-Fluorobenzaldehyde
459-57-4
- US $1.00 / KG
- 99%
- Hebei Weibang Biotechnology Co., Ltd
459-57-4(4-Fluorobenzaldehyde)Related Search:
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PFAD
PFBA
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4-Fluorobenzaldehyde CAS.459-57-4
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4-Fluorobenzaldehyde， ≥ 97.0%
459-57-4
459-57-0
2615-30-4
Organic Building Blocks
C7
Carbonyl Compounds
Aldehydes
Building Blocks
Aldehydes
C7
Carbonyl Compounds
Fluoro-Aromatics
Benzaldehyde
Fluorobenzene