ChemicalBook >> CAS DataBase List >>4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
![4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Structure](CAS2/GIF/870070-55-6.gif)
- CAS No.
- 870070-55-6
- Chemical Name:
- 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
- Synonyms
- CS-297;SYN-115;RO4494351;Tozadenant;RO 4494351;RO-4494351;SYN-115 (Tozadenant);Tozadenant (SYN-115);SYN-115;SYN115;SYN 115;4-Hydroxy-N-[4-methoxy-7-...
- CBNumber:
- CB42514635
- Molecular Formula:
- C19H26N4O4S
- Molecular Weight:
- 406.5
- MDL Number:
- MFCD21642026
- MOL File:
- 870070-55-6.mol
- MSDS File:
- SDS
Last updated:2024-07-02 08:55:08
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Properties
| Density | 1.374 |
|---|---|
| storage temp. | Store at -20°C |
| solubility | insoluble in EtOH; insoluble in H2O; ≥20.35 mg/mL in DMSO |
| form | Powder |
| pka | 14.95±0.20(Predicted) |
| color | White to off-white |
| FDA UNII | D9K857J81I |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P280-P305+P351+P338 | |||||||||
| NFPA 704 |
|
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 28452 | Tozadenant | 870070-55-6 | 10mg | $62 | 2024-03-01 | Buy |
| Cayman Chemical | 28452 | Tozadenant | 870070-55-6 | 25mg | $113 | 2024-03-01 | Buy |
| Cayman Chemical | 28452 | Tozadenant | 870070-55-6 | 50mg | $194 | 2024-03-01 | Buy |
| Cayman Chemical | 28452 | Tozadenant | 870070-55-6 | 100mg | $330 | 2024-03-01 | Buy |
| ApexBio Technology | A3885 | Tozadenant | 870070-55-6 | 50mg | $585 | 2021-12-16 | Buy |
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Chemical Properties,Uses,Production
Description
Tozadenant is an adenosine A2A receptor antagonist (Kis = 11.5 and 6 nM for the human and rhesus monkey receptors, respectively). It increases the distance traveled and reduces contralateral asymmetry in the open field test in a rat model of Parkinson''s disease induced by 6-OHDA when administered at a dose of 30 mg/kg. Tozadenant (150 mg/kg) reverses locomotor deficits and restores novel object-stimulated locomotion in a marmoset model of MPTP-induced Parkinson''s disease.
Definition
ChEBI: Tozadenant is a member of benzothiazoles.
target
adenosine A2A receptor
References
hauser ra, olanow cw, kieburtz kd et al. tozadenant (syn115) in patients with parkinson's disease who have motor fluctuations on levodopa: a phase 2b, double-blind, randomised trial. lancet neurol. 2014 aug;13(8):767-76.
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 69)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Biochempartner | 0086-13720134139 | candy@biochempartner.com | CHINA | 965 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30239 | 58 |
| Baoji Guokang Bio-Technology Co., Ltd. | 0917-3909592 13892490616 | gksales1@gk-bio.com | China | 9312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Coresyn Pharmatech Co., Ltd. | +86-571-86626709 +86-18157142896 | cbc@coresyn.com | China | 9984 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| Suzhou ARTK Medchem Co., Ltd. | +86-512-68323658 +86-18168183658 | sales1@artkmedchem.com | China | 39004 | 58 |
View Lastest Price from 4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-13 | Tozadenant
870070-55-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd | |
 |
2021-07-09 | Tozadenant
870070-55-6
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- Tozadenant
870070-55-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
-
- Tozadenant
870070-55-6
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide Spectrum
4-Hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-1-piperidinecarboxamide
SYN-115
4-Hydroxy-N-[4-methoxy-7-...
Tozadenant
4-hydroxy-N-(4-methoxy-7-morpholinobenzo[d]thiazol-2-yl)-4-methylpiperidine-1-carboxamide
Tozadenant (SYN-115)
SYN-115 (Tozadenant)
1-Piperidinecarboxamide, 4-hydroxy-N-[4-methoxy-7-(4-morpholinyl)-2-benzothiazolyl]-4-methyl-
CS-297
SYN-115;SYN115;SYN 115
4-Methoxy-7-morpholino-2-[(4-hydroxy-4-methylpiperidino)carbonylamino]benzothiazole
P1 receptor,SYN-115,Adenosine Receptor,SYN 115,Tozadenant,Inhibitor,inhibit
RO 4494351
RO4494351
RO-4494351
870070-55-6