2-Chloro-5-chloromethylthiazole
- CAS No.
- 105827-91-6
- Chemical Name:
- 2-Chloro-5-chloromethylthiazole
- Synonyms
- ccmt;2-CHLORO-5-CHLOROMETHYL-1,3-THIAZOLE;oro-5-(chL;2-Chloro-5-chl;2-Chloro-5-chloromet;2-Chloro-5-Chloromethyl;Clomethiazolum Impurity 4;2-CHLORO-5-CHLOROMETHYLTHIAZOLE;2-Chloro-5-chloromehtylthiazole;2-Chloro-5-(chlormethyl)thiazole
- CBNumber:
- CB0366188
- Molecular Formula:
- C4H3Cl2NS
- Molecular Weight:
- 168.04
- MDL Number:
- MFCD01073549
- MOL File:
- 105827-91-6.mol
- MSDS File:
- SDS
Melting point | 31 |
---|---|
Boiling point | 268.6±32.0 °C(Predicted) |
Density | 1.503±0.06 g/cm3(Predicted) |
refractive index | n20/D1.571 |
storage temp. | Keep in dark place,Inert atmosphere,2-8°C |
solubility | soluble in Methanol |
pka | 0.19±0.10(Predicted) |
color | White to Light yellow |
BRN | 5861439 |
InChI | InChI=1S/C4H3Cl2NS/c5-1-3-2-7-4(6)8-3/h2H,1H2 |
InChIKey | VRMUIVKEHJSADG-UHFFFAOYSA-N |
SMILES | S1C(CCl)=CN=C1Cl |
CAS DataBase Reference | 105827-91-6(CAS DataBase Reference) |
FDA UNII | 857BYZ5HZD |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() ![]() ![]() GHS05,GHS06,GHS09 |
---|---|
Signal word | Danger |
Hazard statements | H302-H311-H314-H317-H411 |
Precautionary statements | P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338-P501 |
Hazard Codes | Xi,N,T |
Risk Statements | 36/37/38-51/53-43-34-24-22 |
Safety Statements | 26-37-61-45-36/37/39 |
RIDADR | 2922 |
WGK Germany | 3 |
Hazard Note | Irritant |
HazardClass | 8 |
PackingGroup | Ⅱ |
HS Code | 29349990 |
2-Chloro-5-chloromethylthiazole price More Price(28)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
TCI Chemical | C3295 | 2-Chloro-5-(chloromethyl)thiazole | 105827-91-6 | 5G | $26 | 2024-03-01 | Buy |
TCI Chemical | C3295 | 2-Chloro-5-(chloromethyl)thiazole | 105827-91-6 | 25G | $84 | 2024-03-01 | Buy |
TRC | C367145 | 2-Chloro-5-(chloromethyl)thiazole | 105827-91-6 | 5g | $45 | 2021-12-16 | Buy |
TRC | C367145 | 2-Chloro-5-(chloromethyl)thiazole | 105827-91-6 | 25g | $70 | 2021-12-16 | Buy |
TRC | C367145 | 2-Chloro-5-(chloromethyl)thiazole | 105827-91-6 | 50g | $95 | 2021-12-16 | Buy |
2-Chloro-5-chloromethylthiazole Chemical Properties,Uses,Production
Description
2-Chloro-5-chloromethylthiazole is used as pharmaceutical and agrochemical intermediate. It is also used as intermediate of insecticides Thiamethoxam and Clothianidin. It is also useful in in the synthesis of Ritonavir (R535000); a second-generation anti-AIDS drug and a selective HIV protease inhibitor.
Chemical Properties
White crystal or powder
Uses
2-Chloro-5-(chloromethyl)thiazole is a useful synthetic intermediate used in the synthesis of Ritonavir (R535000)
Synthesis
To a 2-liter round bottomed flask equipped with a mechanical stirrer, thermometer and a condenser, whose outlet was vented into an aqueous sodium hydroxide trap, was charged the crude mixture of cis- and trans-3-chloropropenyl isothiocyanates (504.2 g, 3.79 mol) and chloroform (600 mL). The mixture was stirred and heated to reflux. Chlorine (267.1 g, 3.77 mole) gas was bubbled under the surface of the reaction over a period of 6-8 h. The conversion of the isothiocyanates to 2-chloro-5- (chloromethyl)thiazole was monitored by GC. When the reaction was shown to be complete by GC analysis, the reaction mixture was cooled and then filtered. The filtrate was concentrated on the rotary evaporator to remove chloroform. Sodium bicarbonate (approximately 0.25 equivalents) was added to the concentrated filtrate, and the product 2-chloro-5-chloromethylthiazole was distilled at 97 °C under vacuum (6mm/Hg). The yield after distillation was 43%. 1 H NMR (CDCl3) δ: 7.3 (s, 1H); 4.6 (s, 2H). 13C NMR (CDCl3) δ: 152.6 (C-2); 140.2 (C-4); 137.5 (C-5); 37.1 (-CH2-).
2-Chloro-5-chloromethylthiazole Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
AS WATER CO., LTD. | +86-18994963526 +8618994963526 | 1346073549@qq.com | United Kingdom | 176 | 58 |
Hebei Chuanghai Biotechnology Co,.LTD | +86-13131129325 | sales1@chuanghaibio.com | China | 5878 | 58 |
Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18141 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20255 | 58 |
Capot Chemical Co.,Ltd. | +86-(0)57185586718 +86-13336195806 | sales@capot.com | China | 29730 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-+86-371-66670886 | info@dakenam.com | China | 19852 | 58 |
Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21631 | 55 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | FandaChem@Gmail.com | China | 5904 | 55 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +8618949832763 | info@tnjchem.com | China | 2986 | 55 |
View Lastest Price from 2-Chloro-5-chloromethylthiazole manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
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2025-03-14 | 2-Chloro-5-chloromethylthiazole
105827-91-6
|
US $0.00 / Kg/Drum | 1Kg/Drum | 99% | 5000KG | Hebei Mujin Biotechnology Co.,Ltd | |
![]() |
2025-03-14 | 2-Chloro-5-chloromethylthiazole
105827-91-6
|
US $100.00 / kg | 1kg | 99 | 300tons | Hebei Mujin Biotechnology Co.,Ltd | |
![]() |
2025-03-14 | 2-Chloro-5-chloromethylthiazole
105827-91-6
|
US $50.00 / KG | 1KG | 99% | 5000KG | Hebei Mujin Biotechnology Co.,Ltd |
-
- 2-Chloro-5-chloromethylthiazole
105827-91-6
- US $0.00 / Kg/Drum
- 99%
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2-Chloro-5-chloromethylthiazole
105827-91-6
- US $100.00 / kg
- 99
- Hebei Mujin Biotechnology Co.,Ltd
-
- 2-Chloro-5-chloromethylthiazole
105827-91-6
- US $50.00 / KG
- 99%
- Hebei Mujin Biotechnology Co.,Ltd